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The contribution of antibiotic exposure in the prenatal, peripartum and infancy period to intestinal microbiome perturbations and association with early childhood obesity.

Award Number: K23HD099240
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

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The research program proposed herein is to support the development of Suchitra Hourigan, MD, into an independent investigator aiming to conduct novel and transformative research into the role of gut microbiome development in early childhood health and disease, with a focus on obesity. She seeks a K23 award in order to obtain the skill set, knowledge, formalized training and mentored research experience critical for her transition from an early career physician-scientist with a solid foundation in the basics of trial design, recruitment, epidemiology and microbiome analysis to an independent scientist who conducts trials designed to intervene on microbial communities that contribute to childhood disease. Two essential components of her transition into research independence are hands-on mentored training in 1) the conduct and design of trials and translational microbiome studies and 2) the interpretation of longitudinal microbiome analysis combined with rich epidemiological data. The proposed K23 Career Development plan will accomplish these goals. Obesity is a worldwide epidemic. There is a critical window in very early life that is conjectured to be predictive of later obesity risk, in part due to the establishment of the gut microbiome and metabolic programming that occur. Epidemiological studies have indicated that early exposure to antibiotics increases the risk of childhood obesity. It is hypothesized that early antibiotic exposure causes detrimental gut microbiota perturbations that ‘program’ the host to an obesity-prone metabolic phenotype which persists after discontinuation of antibiotics; however this has never been shown in humans. To test this hypothesis, prospective longitudinal studies with microbiome analysis are needed. The overall goal of this project is to determine the relative contributions of antibiotic exposure in the prenatal, peripartum and infancy period to intestinal microbiome perturbations and association with early childhood obesity. This will be achieved by leveraging the infrastructure of the unique established longitudinal cohort study at Inova (NIH-NICHD ECHO 4UH3OD023337-03). Dr. Hourigan will carry out this proposal in the rich research environment of the Inova Translational Medicine Institute with additional training at the Johns Hopkins School of Medicine where she remains a faculty member. Under the collaborative and supportive mentorship of her primary mentor Dr. John Niederhuber, MD (Executive Vice President of the Inova Health System and CEO of the Genomics and Bioinformatics Research Institute at Inova), co-mentor Dr. Cynthia Sears, MD (Professor of Medicine in the Division of Infectious Disease and Gastroenterology, Johns Hopkins) and advisors, she is well positioned to complete the proposed activities. In addition to leading this research, Dr. Hourigan will attend courses, workshops, scientific meetings and participate in weekly study activities with her mentors. This mentored training will enable Dr. Hourigan to grow into an independent researcher, with expertise in the design, conduct and analysis of longitudinal microbiome studies, focused on understanding role of the developing gut microbiome in childhood health outcomes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = -$105,649 )
2022	2021	INOVA HEALTH CARE SERVICES	8110 GATEHOUSE RD STE 200E	FALLS CHURCH	VA	22042	FAIRFAX	USA	Child Health and Human Development Extramural Research	000	3	2/28/2022	NON-COMPETING CONTINUATION	-$105,649
														Subtotal = -$105,649

Issue Date FY: 2021 ( Subtotal = $158,760 )
2021	2021	INOVA HEALTH CARE SERVICES	8110 GATEHOUSE RD STE 200E	FALLS CHURCH	VA	22042	FAIRFAX	USA	Child Health and Human Development Extramural Research	000	3	6/22/2021	NON-COMPETING CONTINUATION	$158,760
2021	2021	INOVA HEALTH CARE SERVICES	8110 GATEHOUSE RD STE 200E	FALLS CHURCH	VA	22042	FAIRFAX	USA	Child Health and Human Development Extramural Research	001	3	8/24/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $158,760

Issue Date FY: 2020 ( Subtotal = $158,760 )
2020	2020	INOVA HEALTH CARE SERVICES	8110 GATEHOUSE RD STE 200E	FALLS CHURCH	VA	22042	FAIRFAX	USA	Child Health and Human Development Extramural Research	000	2	6/10/2020	NON-COMPETING CONTINUATION	$158,760
														Subtotal = $158,760

Issue Date FY: 2019 ( Subtotal = $158,760 )
2019	2019	INOVA HEALTH CARE SERVICES	8110 GATEHOUSE RD STE 200E	FALLS CHURCH	VA	22042	FAIRFAX	USA	Child Health and Human Development Extramural Research	000	1	7/23/2019	NEW	$158,760
														Subtotal = $158,760

Grand Total All Awards = $370,631

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The contribution of antibiotic exposure in the prenatal, peripartum and infancy period to intestinal microbiome perturbations and association with early childhood obesity.

Award Number: K23HD099240

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

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