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Psychophysiology and Social Processes in Very Young Children with Externalizing Problems

Award Number: K23HD096052
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 12/01/2023
PERIOD OF PERFORMANCE END DATE: 12/31/2024

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Psychophysiology and Social Processes in Very Young Children with Externalizing Problems - PROJECT SUMMARY / ABSTRACT The candidate’s long-term goal is to develop an independent research career to understand risk factors for the development of externalizing behavior over the lifespan. The proposed training plan outlines four objectives critical to achieving this goal: 1) extend expertise in the acquisition and analysis of psychophysiological variables, 2) obtain research experience with young children, 3) obtain training in statistical techniques to test for mediation/moderation, and 4) gain practical skills for research independence. Oppositional defiant disorder (ODD) is prevalent in preschool age children, and its presence substantially increases the risk of developing a full range of other psychiatric disorders. Prior work has differentiated dimensions of ODD (irritability, defiance, vindictiveness) that show differential relationships with later psychopathology; however, the dimensions are highly correlated. Thus, children with oppositionality have similar phenotypic presentations despite being a heterogeneous group with differing longitudinal trajectories. It is proposed that phenotypic symptoms mask the underlying processes that carry differential risks, and that opposing processes in arousal/regulation and social processes systems can lead to both phenotypically similar presentations and explain differences in longitudinal development. Three specific aims are proposed: 1) Identify opposing arousal/regulation processes that differentiate irritability and vindictiveness. 2) Identify opposing social processes that differentiate irritability and vindictiveness. 3) Examine the combined effects of arousal/regulation and social processes in predicting irritability and vindictiveness. It is expected that defiance will be highly correlated with both irritability and vindictiveness, explaining phenotypic similarity. The applicant will accomplish these aims by assessing 175 4-6 year-old children in the greater New Orleans area identified as having behavioral problems. Assessments will include indices of arousal/regulation (pre-ejection period, heart rate variability, and electrodermal response) during baseline or an emotion induction task, and indices of social processes (accuracy and bias in facial emotion recognition). The proposed research will take place at Tulane University in New Orleans, LA and the Child Counseling Associates clinic in Metairie, LA. The anticipated outcome is that irritability will be related to high physiological arousal and an attentional bias toward negative emotional stimuli, whereas vindictiveness will be related to low physiological arousal and deficient emotional recognition abilities. It is expected that these opposing processes will account for the differential relationships with comorbid psychopathology. These results would have the potential to aid the development of individualized interventions to reduce risk for later psychopathology associated with childhood oppositionality. Thus, the proposed research is in line with the high priority goal to identify mechanisms that confer vulnerability to psychiatric illnesses and develop early interventions for reducing the severity and incidence of psychopathology.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	THE ADMINISTRATORS OF TULANE EDUCATIONAL FUND	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Child Health and Human Development Extramural Research	001	5	2/19/2025	NON-COMPETING CONTINUATION	-$7,640
2025	2023	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	Child Health and Human Development Extramural Research	003	6	6/11/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2025	2023	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	Child Health and Human Development Extramural Research	002	6	2/19/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$11,156
2025	2022	THE ADMINISTRATORS OF TULANE EDUCATIONAL FUND	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Child Health and Human Development Extramural Research	000	4	2/19/2025	NON-COMPETING CONTINUATION	-$3,516
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	Child Health and Human Development Extramural Research	001	6	11/27/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$92,880
2024	2023	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Child Health and Human Development Extramural Research	000	5	11/21/2023	NON-COMPETING CONTINUATION	-$92,880
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $100,520 )
2023	2023	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Child Health and Human Development Extramural Research	000	5	5/3/2023	NON-COMPETING CONTINUATION	$100,520
														Subtotal = $100,520

Issue Date FY: 2022 ( Subtotal = $113,550 )
2022	2022	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Child Health and Human Development Extramural Research	000	4	4/18/2022	NON-COMPETING CONTINUATION	$113,550
														Subtotal = $113,550

Issue Date FY: 2021 ( Subtotal = $110,087 )
2021	2021	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Child Health and Human Development Extramural Research	000	3	3/31/2021	NON-COMPETING CONTINUATION	$110,087
														Subtotal = $110,087

Issue Date FY: 2020 ( Subtotal = $103,999 )
2020	2020	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Child Health and Human Development Extramural Research	000	2	4/1/2020	NON-COMPETING CONTINUATION	$103,999
														Subtotal = $103,999

Issue Date FY: 2019 ( Subtotal = $112,628 )
2019	2019	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Child Health and Human Development Extramural Research	000	1	3/19/2019	NEW	$112,628
														Subtotal = $112,628

Grand Total All Awards = $540,784

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Psychophysiology and Social Processes in Very Young Children with Externalizing Problems

Award Number: K23HD096052

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 12/01/2023

PERIOD OF PERFORMANCE END DATE: 12/31/2024

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