DESCRIPTION (provided by applicant): Childhood obesity and food insecurity coexist, largely because both are conditions disproportionately affecting families living in poverty. I am a pediatrician who works in a population with many socioeconomically disadvantaged children, and a researcher who has for years had a strong focused on food access in low- income communities. I am seeking a mentored career award to further develop my skills as a clinical researcher in order to achieve my goal of becoming an independently-funded investigator conducting research on policy-relevant strategies and interventions that improve the metabolic risk and long-term health of obese children who live in poverty. Preliminary studies with my patients exploring how our food-insecure patients differ from their food-secure peers have informed this proposal. Qualitative work has led to my hypothesis that food-insecure obese patients have a higher propensity towards disordered eating, and preliminary analysis with NHANES suggests that they have greater metabolic dysregulation than their food-secure peers. I am now broadening my investigations about the potential metabolic impact of food insecurity to include other more upstream markers of insulin resistance and metabolic risk. Key elements of my proposed research activities include the following: A. In order to refine understanding of the impact of food-insecurity on diet in food-insecure children, I will recruit 80 patients in order t conduct a more detailed investigation of their dietary intake and eating behaviors than is typically feasible in the context of routine clinic. B. These same 80 obese patients (8-14 yrs.) wil have laboratory testing done to assess how overall cardio-metabolic risk (evidenced by insulin resistance or the presence of more atherogenic lipoprotein profile) compares between food-insecure children and their low-income peers. C. Conduct a randomized intervention using physician-delivered supermarket vouchers for fruits, vegetables, and whole fiber foods among 60 low-income, obese children (8 to 14 years) who are in a household that uses SNAP ("food stamps"). Determine impact on behavior, BMI, and biomarkers of metabolic risk. In order to solidify my knowledge base regarding nutrition measurement, consolidate statistical analysis skills, and conduct a well-executed randomized intervention, I will take relevant coursework available to me on two University of California campuses. My mentorship team is well qualified to assist me not only with completing these proposed research activities, but also with launching my career as an independent clinical scientist.