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NOVEL PELVIC FLOOR PAIN MEASURES TO ENHANCE FEMALE PELVIC PAIN EVALUATION

Award Number: K23HD054645
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 09/15/2008
PERIOD OF PERFORMANCE END DATE: 08/31/2013

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NOVEL PELVIC FLOOR PAIN MEASURES TO ENHANCE FEMALE PELVIC PAIN EVALUATION - DESCRIPTION (provided by applicant): A major shortcoming in the present diagnostic framework for painful bladder syndrome (PBS) and related pelvic pain disorders is the failure to incorporate objective measures of pain sensitivity. As a gynecologist, the applicant's long-term research goal is to define modifiable disease mechanisms in urogenital pain syndromes. Through the present application, he seeks training in the physiological assessment of pain in order to mechanistically subtype pelvic pain patients. At present, failure to systematically diagnose heterogeneous etiologies in pelvic pain hinders the rational use of specific interventions. A two part-program is proposed. First, under a structured program of mentorship (drawn from gynecology, urology, gastroenterology, psychology, physiology, and neurology) he will study relevant pain physiology and pertinent correlates of the human pain experience. The candidate will engage in both formal didactic and experiential training in design of multi-site clinical trials, assessment of pain physiology in diseased states, and characterization of psychological determinants of pain experience. Simultaneously, he will gain practical experience while conducting a prospective observational study of one important but understudied aspect of PBS and related pelvic pain syndromes: pelvic floor pain dysfunction. The central hypothesis is that women suffering from PBS have increased pelvic floor pain sensitivity (i.e., worse pain when the muscles are examined by a clinician) compared to healthy controls. This hypothesis will be tested using three specific aims: 1) Determine whether pelvic floor (somatic) pain sensitivity is enhanced in PBS; 2) Determine correlates of enhanced bladder (visceral) pain sensitivity; and 3) To correlate urogenital distress among PBS patients and pain-free controls with pelvic muscle pain sensitivity, visceral pain sensitivity, and psychological factors. The approach is innovative, by employing accepted pain assessment tools to an important, understudied area: the pelvic floor musculature. The research proposed in this application is significant for improving diagnosis of PBS and other pelvic pain syndromes in both women and men. Objective, valid measures of pelvic floor pain dysfunction will allow rational application of mechanism-specific treatments, such as physical therapy, neuropathic pain medications, cognitive-behavioral therapy, or botulinum toxin injections. Public Narrative: The outcomes of this study will likely enhance our approach to the assessment of pain symptomatology not only in PBS, but in all pelvic pain syndromes associated with pelvic floor sensitivity or irritative voiding symptoms.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2012 ( Subtotal = $108,000 )
2012	2012	NORTHSHORE UNIVERSITY HEALTHSYSTEM RESEARCH INSTITUTE	1001 UNIVERSITY PLACE	EVANSTON	IL	60201	COOK	USA	Child Health and Human Development Extramural Research	000	5	8/1/2012	NON-COMPETING CONTINUATION	$108,000
														Subtotal = $108,000

Issue Date FY: 2011 ( Subtotal = $108,000 )
2011	2011	NORTHSHORE UNIVERSITY HEALTHSYSTEM RESEARCH INSTITUTE	1001 UNIVERSITY PLACE	EVANSTON	IL	60201	COOK	USA	Child Health and Human Development Extramural Research	000	4	8/5/2011	NON-COMPETING CONTINUATION	$108,000
														Subtotal = $108,000

Issue Date FY: 2010 ( Subtotal = $108,000 )
2010	2010	NORTHSHORE UNIVERSITY HEALTHSYSTEM RESEARCH INSTITUTE	1001 UNIVERSITY PLACE	EVANSTON	IL	60201	COOK	USA	Child Health and Human Development Extramural Research	000	3	8/4/2010	NON-COMPETING CONTINUATION	$108,000
														Subtotal = $108,000

Issue Date FY: 2009 ( Subtotal = $108,000 )
2009	2009	NORTHSHORE UNIVERSITY HEALTHSYSTEM RESEARCH INSTITUTE	1001 UNIVERSITY PLACE	EVANSTON	IL	60201	COOK	USA	Population Research	000	2	8/25/2009	NON-COMPETING CONTINUATION	$108,000
														Subtotal = $108,000

Issue Date FY: 2008 ( Subtotal = $108,000 )
2008	2008	EVANSTON NORTHWESTERN HEALTHCARE RESEARCH INSTITUTE	2650 RIDGE AVENUE	EVANSTON	IL	60201	COOK	USA	Population Research	000	1	9/15/2008	NEW	$108,000
														Subtotal = $108,000

Grand Total All Awards = $540,000

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NOVEL PELVIC FLOOR PAIN MEASURES TO ENHANCE FEMALE PELVIC PAIN EVALUATION

Award Number: K23HD054645

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 09/15/2008

PERIOD OF PERFORMANCE END DATE: 08/31/2013

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