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Improving Individualized Assessments of Glaucoma Progression with Population-Based Electronic Health Record Data

Award Number: K23EY033831
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 06/01/2022
PERIOD OF PERFORMANCE END DATE: 03/31/2027

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Improving Individualized Assessments of Glaucoma Progression with Population-Based Electronic Health Record Data - PROJECT SUMMARY Swarup S. Swaminathan, MD is an Assistant Professor of Ophthalmology at the Bascom Palmer Eye Institute with a career goal of becoming an independent clinician-scientist in the field of glaucoma clinical research. His overall research focus is to utilize novel statistical and data science methodologies to improve assessment of progression in glaucoma and early detection of those patients at greatest risk for irreversible vision loss. The primary objectives of this K23 career development proposal are: 1) to compare currently available methods used to monitor glaucomatous disease progression with higher-order Bayesian prediction models equipped with data from electronic health records (EHR), and 2) to provide an academic glaucoma specialist with the mentored research experience and formal training to conduct independent clinical research. Achieving these objectives will provide the critical skills required to establish an independent research program focused on applying data science principles to improve the clinical assessment of progression in glaucoma patients. The proposed K23 application will provide valuable mentorship and formal training in biostatistics, analysis of large databases containing longitudinal data, application of Bayesian statistics in the medical sciences, and artificial intelligence and machine learning data analysis. The extensive technical resources available at the Bascom Palmer Eye Institute and University of Miami Institute for Data Science & Computing, the mentorship and expertise of his advisory committee, and the dedicated institutional commitment will provide Dr. Swaminathan with the support needed to transition into an independent clinician-scientist. He will regularly meet with his mentors and advisors to discuss career development, attend pertinent university seminars and workshops, present ongoing research at national meetings, and consistently submit his work for publication. This proposal will test the hypothesis that EHR-equipped Bayesian models outperform ordinary least square (OLS) regression in accuracy and their ability to detect progression earlier. In Aim 1, Bayesian models equipped with EHR population-level imaging and functional data will be constructed to calculate the rate of change in optical coherence tomography and standard automated perimetry metrics of individual patients. In Aim 2, patient- specific risk factor data will be incorporated into Bayesian models to further refine these individualized predictions. These models will be compared to OLS regression, with the hypothesis that Bayesian models will be superior. Finally, in Aim 3, an interactive application will be developed to gather data from clinical practice in order to validate the use of Bayesian models in clinical care. An expert clinician panel will compare masked OLS and Bayesian estimates from these cases. The results of the proposed research will provide the foundation for an R01 grant examining the use of EHR data to improve clinical decision-making for the longitudinal care of glaucoma patients.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $210,027 )
2025	2025	UNIVERSITY OF MIAMI	1320 S DIXIE HWY STE 1200	CORAL GABLES	FL	33146	MIAMI-DADE	USA	Vision Research	000	4	3/17/2025	NON-COMPETING CONTINUATION	$210,027
														Subtotal = $210,027

Issue Date FY: 2024 ( Subtotal = $206,091 )
2024	2024	UNIVERSITY OF MIAMI	1320 S DIXIE HWY STE 1200	CORAL GABLES	FL	33146	MIAMI-DADE	USA	Vision Research	000	3	4/25/2024	NON-COMPETING CONTINUATION	$206,091
														Subtotal = $206,091

Issue Date FY: 2023 ( Subtotal = $224,665 )
2023	2023	UNIVERSITY OF MIAMI	1400 NW 10TH AVE	MIAMI	FL	33136	MIAMI-DADE	USA	Vision Research	000	2	3/20/2023	NON-COMPETING CONTINUATION	$193,025
2023	2023	UNIVERSITY OF MIAMI	1400 NW 10TH AVE	MIAMI	FL	33136	MIAMI-DADE	USA	Vision Research	001	2	5/22/2023	NON-COMPETING CONTINUATION	$31,640
														Subtotal = $224,665

Issue Date FY: 2022 ( Subtotal = $226,769 )
2022	2022	UNIVERSITY OF MIAMI	1600 NW 10 AVE	MIAMI	FL	33136	MIAMI-DADE	USA	Vision Research	000	1	5/30/2022	NEW	$226,769
														Subtotal = $226,769

Grand Total All Awards = $867,552

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Improving Individualized Assessments of Glaucoma Progression with Population-Based Electronic Health Record Data

Award Number: K23EY033831

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 06/01/2022

PERIOD OF PERFORMANCE END DATE: 03/31/2027

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