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Validating a machine learning model of eye tracking in children with cortical visual impairment (CVI)

Award Number: K23EY033790
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 04/01/2022
PERIOD OF PERFORMANCE END DATE: 03/31/2027

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Validating a machine learning model of eye tracking in children with cortical visual impairment (CVI) - Project summary Cortical visual impairment (CVI) is the leading cause of pediatric visual impairment in developed countries. There is no evidence-based treatment, and design of clinical trials is hampered by the absence of a validated method of visual assessment that captures the numerous aspects of visual function that are compromised in pediatric CVI. Our laboratory is investigating the use of eye tracking in children with CVI. During eye tracking, an infrared camera tracks the pupillary and corneal light reflections while a child watches visual stimuli on a computer monitor. The eye tracker calculates the direction of eye gaze with high spatial and temporal frequency. Our eye tracking protocol assesses multiple afferent, efferent, and higher-order visual parameters during a 12-minute recording session. Our initial data show that eye tracking is reliable and quantifies multiple visual and oculomotor parameters in children with CVI. Given the large amount of data generated by eye tracking (2,000 data points per second), higher-level analytics are required. We will validate a machine-learning model of eye tracking in children with CVI via three Specific Aims. In Aim 1, we will quantify deficits of visual function in pediatric CVI using eye tracking, strengthening the findings in our preliminary data by inclusion of a well-powered sample. In Aim 2, we will use machine learning to develop a CVI eye tracking severity score. In Aim 3, we will validate eye tracking by comparing and contrasting with two other methods of visual assessment in children with CVI, sweep visual evoked potentials and the CVI Range. Together, these studies will establish eye tracking as a quantitative, objective, and comprehensive measure of visual function in pediatric CVI. In the R01 application planned at the end of the K23 award period, we will incorporate the CVI eye tracking severity score as an outcome measure in a longitudinal study of standard and targeted therapies for CVI. In pursuit of these aims, I will be mentored by a highly experienced, interdisciplinary, internationally recognized team at Children’s Hospital Los Angeles and University of Southern California. Under their guidance, I will also pursue a Masters degree in Applied Data Science and gain experiential learning in electrophysiology. The training acquired during my Career Development Award will enable me to transition to an independent investigator leading a research program focused on developing next-generation technologies to interrogate the visual system in children with a variety of neurodevelopmental disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $234,604 )
2025	2025	CHILDREN'S HOSPITAL LOS ANGELES	4650 W SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Vision Research	000	4	3/26/2025	NON-COMPETING CONTINUATION	$234,604
														Subtotal = $234,604

Issue Date FY: 2024 ( Subtotal = $234,603 )
2024	2024	CHILDREN'S HOSPITAL LOS ANGELES	4650 W SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Vision Research	000	3	4/9/2024	NON-COMPETING CONTINUATION	$234,603
														Subtotal = $234,603

Issue Date FY: 2023 ( Subtotal = $234,603 )
2023	2023	CHILDRENS HOSPITAL LOS ANGELES	4650 W SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Vision Research	000	2	4/3/2023	NON-COMPETING CONTINUATION	$234,603
														Subtotal = $234,603

Issue Date FY: 2022 ( Subtotal = $234,603 )
2022	2022	CHILDRENS HOSPITAL LOS ANGELES	4650 SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Vision Research	000	1	3/21/2022	NEW	$234,603
														Subtotal = $234,603

Grand Total All Awards = $938,413

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Validating a machine learning model of eye tracking in children with cortical visual impairment (CVI)

Award Number: K23EY033790

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 04/01/2022

PERIOD OF PERFORMANCE END DATE: 03/31/2027

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