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Role of optical aberrations in 3D space perception: Implications for Keratoconus

Award Number: K23EY024691
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 09/01/2014
PERIOD OF PERFORMANCE END DATE: 06/30/2021

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Role of optical aberrations in 3D space perception: Implications for Keratoconus - DESCRIPTION (provided by applicant): The following is a summary of Dr. Sangeetha Metlapally's Mentored Clinical Scientist Research Career Development Award (K23) application. Keratoconus is a progressive, degenerative condition characterized by corneal thinning and steepening, leading to increased optical aberrations. The socio-economic liability and impact on the quality of life of visual deficits in this condition is disproportionate, affecting predominanty young adults during prime earning and child-rearing years. Increased magnitudes of optical higher-order aberrations (HOAs) and inter- ocular asymmetries in the aberrations are common, and could potentially lead to problems with binocular space perception, which is not well understood in this subject population. Current clinical management paradigms concentrate heavily on maximizing monocular high-contrast visual acuities, which do not address losses in stereoscopic depth perception, as seen in our preliminary data. The planned research program addresses the issue of irregular corneal optics leading to impaired binocular space perception in keratoconus or post-LASIK. The results may apply to the qualitatively similar effects of irregular optics on vision due to aberrations in other conditions like pellucid marginal degeneration, post-LASIK keratectasias or following corneal transplants. There are three independent optical factors that could contribute to the loss of stereoscopic depth perception. Inter-ocular asymmetries in lower-order aberrations (LOAs) and HOAs could cause inter-ocular contrast differences reducing stereo-acuity. Further, aniseikonia, due to refractive anisometropia corrected with spectacles, would produce distortions of perceived space and interfere with stereopsis. Thirdly inter-ocular phase differences produced by aberrations could produce false-binocular matches that would lower the strength of disparity signals for stereo-depth. We hypothesize, therefore, that some or all of the above, resulting from increased aberrations and inter-ocular optical asymmetries can lead to loss of stereoscopic depth perception and distortions in the three dimensional perception of space. Our goal is to compare performance with contact lens corrections, which minimize the contribution of HOAs, and spectacle lens corrections, by way of investigating the influence of disease-related or surgically-induced HOAs on stereo-depth perception. The proposed research is novel and innovative as it uses powerful, validated tools to collect and analyze optical wave front data and examines the yet unknown effects of irregular optics on binocular space perception. We hope that the proposed aims will lead to a better understanding of the inter-relationships between irregular optics and binocular vision, and directly translate to optical or other management strategies in the clinic that will better serve to improve spatial vision in individuals with keratoconus or irregular corneal optics.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = -$4,455 )
2022	2018	THE NEW ENGLAND COLLEGE OF OPTOMETRY	424 BEACON ST	BOSTON	MA	02115	SUFFOLK	USA	Vision Research	000	6	11/27/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$4,455
														Subtotal = -$4,455

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2018	NEW ENGLAND COLLEGE OF OPTOMETRY, THE	424 BEACON ST	BOSTON	MA	02115	SUFFOLK	USA	Vision Research	000	6	5/29/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	Vision Research	000	5	12/10/2018	NON-COMPETING CONTINUATION	-$89,032
2019	2018	NEW ENGLAND COLLEGE OF OPTOMETRY, THE	424 BEACON ST	BOSTON	MA	02115	SUFFOLK	USA	Vision Research	001	6	12/10/2018	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$89,032
2019	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Vision Research	002	5	4/23/2019	NON-COMPETING CONTINUATION	-$47,927
2019	2018	NEW ENGLAND COLLEGE OF OPTOMETRY, THE	424 BEACON ST	BOSTON	MA	02115	SUFFOLK	USA	Vision Research	003	6	4/23/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$47,927
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = $155,849 )
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	Vision Research	000	5	6/18/2018	NON-COMPETING CONTINUATION	$155,849
														Subtotal = $155,849

Issue Date FY: 2017 ( Subtotal = $155,849 )
2017	2017	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	Vision Research	000	4	6/21/2017	NON-COMPETING CONTINUATION	$155,849
														Subtotal = $155,849

Issue Date FY: 2016 ( Subtotal = $155,849 )
2016	2016	UNIVERSITY OF CALIFORNIA, REGENTS	481 UNIVERSITY HALL	BERKELEY	CA	94704	ALAMEDA	USA	Vision Research	000	3	6/28/2016	NON-COMPETING CONTINUATION	$155,849
														Subtotal = $155,849

Issue Date FY: 2015 ( Subtotal = $155,849 )
2015	2015	UNIVERSITY OF CALIFORNIA, REGENTS	481 UNIVERSITY HALL	BERKELEY	CA	94704	ALAMEDA	USA	Vision Research	000	2	6/23/2015	NON-COMPETING CONTINUATION	$155,849
														Subtotal = $155,849

Issue Date FY: 2014 ( Subtotal = $155,849 )
2014	2014	UNIVERSITY OF CALIFORNIA, REGENTS	481 UNIVERSITY HALL	BERKELEY	CA	94704	ALAMEDA	USA	Vision Research	000	1	8/6/2014	NEW	$155,849
														Subtotal = $155,849

Grand Total All Awards = $774,790

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Role of optical aberrations in 3D space perception: Implications for Keratoconus

Award Number: K23EY024691

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 09/01/2014

PERIOD OF PERFORMANCE END DATE: 06/30/2021

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