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Optimizing an Adaptive Self-care Support Intervention for Adults with Type 2 Diabetes Leveraging their Social Relationships

Award Number: K23DK140531
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 08/01/2024
PERIOD OF PERFORMANCE END DATE: 04/30/2029

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Optimizing an Adaptive Self-care Support Intervention for Adults with Type 2 Diabetes Leveraging their Social Relationships - Project Summary/Abstract Successful management of type 2 diabetes (T2D) requires daily self-care behaviors which largely occur within the context of patients’ social relationships. Chronic diseases, like T2D, have high levels of heterogeneity in response to self-care support interventions, suggesting a sequential, individualized approach may maximize benefits for the largest proportion of patients. Adaptive interventions mirror clinical care by applying a series of “if-then” decision rules that dictate which intervention components are delivered over time, according to how individuals respond. They are especially well suited to the management of chronic conditions. To date, all adaptive interventions for chronic disease management are delivered individually; none have involved social support. Adaptive interventions leveraging social relationships could reduce heterogeneity in response to self- care support interventions and better meet the needs of adults with T2D. During this K23 award, the principal investigator (PI) will address these gaps in the extant literature while participating in a mentored training experience that will prepare her for success as an independent investigator who develops and tests adaptive interventions to improve the health and well-being of adults with T2D by leveraging the power of social support. Specific training goals include: (1) deepen knowledge in behavioral diabetes research, (2) develop skills in qualitative and mixed methods, (3) apply Multiphase Optimization Strategy (MOST) framework to develop and optimize adaptive interventions, and (4) lead a clinical trial and strengthen responsible conduct of research skills. The proposed research includes two specific aims. Aim 1: The PI will adapt components of an evidence- based family-focused self-care support intervention to target peer-support rather than family-support. Adults with T2D (n=30) will be recruited to participate in focus groups and iterative rounds of testing to refine the peer- support components prior to evaluation. A community engagement studio will advise protocols and recruitment. Aim 2: The PI will recruit and randomize 60 adults with T2D to a pilot sequential multiple assignment randomized trial (SMART) to test the acceptability and feasibility of random assignment to multiple social- support focused interventions. The PI will report on the feasibility and acceptability of this innovative approach to adaptive interventions as well as conduct interviews with participants to further improve the interventions through a robust mixed-methods evaluation. Improvements, if needed, will be made prior to proposing a fully powered SMART to optimize the adaptive interventions. At the conclusion of this work, the PI will have robust preliminary data on the feasibility and acceptability of optimization methodology in adults with T2D, namely multiple randomizations to social support-focused interventions, to inform a R01-funded SMART. This unique expertise will accelerate the PI’s independent research career as an expert in adaptive interventions for adults with T2D. Moreover, it will help the PI reach her ultimate goal of developing and testing adaptive interventions to improve health and well-being of adults with T2D leveraging their social relationships.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $186,624 )
2026	2026	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	4/21/2026	NON-COMPETING CONTINUATION	$186,624
														Subtotal = $186,624

Issue Date FY: 2025 ( Subtotal = $186,624 )
2025	2025	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	4/29/2025	NON-COMPETING CONTINUATION	$186,624
														Subtotal = $186,624

Issue Date FY: 2024 ( Subtotal = $186,616 )
2024	2024	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	7/24/2024	NEW	$186,616
														Subtotal = $186,616

Grand Total All Awards = $559,864

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Optimizing an Adaptive Self-care Support Intervention for Adults with Type 2 Diabetes Leveraging their Social Relationships

Award Number: K23DK140531

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 08/01/2024

PERIOD OF PERFORMANCE END DATE: 04/30/2029

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