Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Contribution of Nutrient Delivery Rate to Gut-Brain Axis Signaling in Obesity and Bariatric Surgery

Award Number: K23DK138261
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 08/01/2024
PERIOD OF PERFORMANCE END DATE: 04/30/2028

Group Awards By:

View Award Description

Contribution of Nutrient Delivery Rate to Gut-Brain Axis Signaling in Obesity and Bariatric Surgery - PROJECT SUMMARY/ABSTRACT Mechanisms underlying sustained weight loss after bariatric surgery remain unclear, though rapid nutrient delivery is a major candidate driving decreases in caloric intake via the gut-brain axis. Preclinical models have demonstrated the importance of the gut-brain axis in modulating short- and long-term feeding and taste preferences through gut-brain neural connections and the endocrine gut peptide response. Our clinical preliminary data demonstrates that rapid intestinal nutrient infusion (bypassing the stomach) in non-surgical patients with obesity can mimic the augmented gut-brain endocrine response (e.g. GLP-1) of bariatric surgery. Our overarching hypothesis is that bariatric surgery induces a chronic state of rapid nutrient delivery leading to hypersecretion of gut peptides known to signal satiety, slow GI motility, and decrease nutrient-rich food preference. This sustained and altered enteral delivery modifies nutrient-stimulated, gut endocrine and gut- brain signaling, which changes feeding behavior and leads to weight loss. In the following project, we will (Aim 1) test the hypothesis that rapid nutrient delivery is associated with augmented GLP-1 and brain fMRI responses. Human subjects being evaluated for bariatric surgery will undergo non-invasive placement of an enteral feeding tube for a variable rate glucose infusion into the small intestine, with concurrent measurement of the rapid brain signaling response using functional magnetic resonance imaging (fMRI) and gut peptide endocrine response. Additionally, we will (Aim 2) test the hypothesis that Roux-en-Y Gastric Bypass (RYGB) is associated with faster nutrient absorption compared to Sleeve Gastrectomy (SG). Preoperative and postoperative measurements of intestinal nutrient uptake will be made with non-metabolizable glucose and amino acid tracers, with measurement of the corresponding gut peptide endocrine responses to understand the putative differences in postoperative absorption of sleeve and gastric bypass. This career development plan is highly innovative, combining enteral nutrient infusion with fMRI to begin to (1) establish rapid intestinal nutrient delivery as a primary driver of the gut endocrine response of bariatric surgery, (2) determine the degree to which the most common bariatric operations increase nutrient absorption, and (3) identify brain regions that are rapidly responsive (within seconds) to enteral nutrient presence similar to preclinical rodent studies. Understanding gut-brain axis physiology and how it is altered by bariatric surgery may lead to identification of novel therapeutic strategies and simpler surgical or endoscopic treatments for obesity. The training plan associated with this career development award allows the PI to gain the necessary training in patient-oriented research and focuses long-term research efforts in studying the gut-brain axis in obesity and bariatric surgery.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $178,740 )
2026	2026	PENNINGTON BIOMEDICAL RESEARCH CENTER	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	4/27/2026	NON-COMPETING CONTINUATION	$178,740
														Subtotal = $178,740

Issue Date FY: 2025 ( Subtotal = $178,740 )
2025	2025	PENNINGTON BIOMEDICAL RESEARCH CENTER	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	4/30/2025	NON-COMPETING CONTINUATION	$178,740
														Subtotal = $178,740

Issue Date FY: 2024 ( Subtotal = $180,240 )
2024	2024	LSU PENNINGTON	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	7/24/2024	NEW	$180,240
														Subtotal = $180,240

Grand Total All Awards = $537,720

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Contribution of Nutrient Delivery Rate to Gut-Brain Axis Signaling in Obesity and Bariatric Surgery

Award Number: K23DK138261

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 08/01/2024

PERIOD OF PERFORMANCE END DATE: 04/30/2028

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer