Wednesday, August 20, 2025 8/20/2025

Time course and predictors of progression to postpartum prediabetes and type 2 diabetes in HIV: a prospective longitudinal study of low-income Indian women

Award Number: K23DK136388
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 05/01/2024
PERIOD OF PERFORMANCE END DATE: 02/28/2029

Group Awards By:

View Award Description

Time course and predictors of progression to postpartum prediabetes and type 2 diabetes in HIV: a prospective longitudinal study of low-income Indian women - PROJECT SUMMARY & ABSTRACT Candidate. Dr. Puja Chebrolu is a physician-scientist who has spent the past five years conducting research on HIV and diabetes in India. She has conducted longitudinal research, developed strong scientific collaborations with Indian scientists, trained an Indian research team, and authored 10 publications. She has documented that HIV increases the risk of gestational diabetes (GDM). She hypothesizes that HIV will also increase the risk of prediabetes (preDM) and type 2 diabetes (T2DM) development postpartum. Career Development Plan. Dr. Chebrolu's immediate and long-term goals are the following: 1) Increase her understanding of HIV-associated diabetes epidemiology and pathogenesis. 2) Increase her skills in advanced biostatistics for longitudinal data 3) Obtain training in the conduct of clinical trials 4) Develop professional skills including leadership and mentorship Dr. Chebrolu will develop these skills through coursework and implementation of her longitudinal study on time course and predictors of progression to postpartum preDM and T2DM in women living with HIV and GDM. Environment. The proposed research and training will take place at Weill Cornell Medicine (USA) and at Byramjee Jeejeebhoy Government Medical College (India). Dr. Chebrolu's mentors have expertise that encompass her goals. They have worked with her and each other previously. Research. Over data two-thirds of women who develop GDM will progress to T2DM within 10 years. suggests that HIV doubles the risk of GDM Dr. Chebrolu's , and is associated with increased risk of progression to T2DM. The impact of HIV on postpartum progression to preDM and T2DM is not known. Preliminary data suggests that South Asian women progress to T2DM faster than obese populations due to low baseline pancreatic beta cell mass. HIV increases beta cell stress through multiple mechanisms and may further accelerate the rate of progression to T2DM. Understanding progression its the impact of HIV on the time course and pathophysiology of T2DM will help inform the timing and type of interventions to prevent or delay progression to T2DM and devastating sequelae. Aim 1: Estimate the time to progression to postpartum prediabetes and T2DM in 180 women with a history of GDM (60 women with HIV and 120 women without HIV). We will test for prediabetes and T2DM at 5 timepoints over 2 years postpartum. This aim will test the hypothesis that hazard of progression to prediabetes or T2DM will be significantly higher in women with GDM and HIV compared to women with GDM and without HIV. Aim 2: Determine the effect of HIV on longitudinal beta cell function in women with a history GDM. The primary hypothesis is that women with HIV and GDM will have a greater rate of decline in pancreatic beta cell function over 2 years postpartum compared to women with GDM and without HIV.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $197,100 )
2025	2025	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	575 LEXINGTON AVE FL 9	NEW YORK	NY	10022	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	2/21/2025	NON-COMPETING CONTINUATION	$197,100
														Subtotal = $197,100

Issue Date FY: 2024 ( Subtotal = $197,100 )
2024	2024	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	575 LEXINGTON AVE FL 9	NEW YORK	NY	10022	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	1	8/21/2024	NEW	$0
2024	2024	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	575 LEXINGTON AVE FL 9	NEW YORK	NY	10022	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	5/1/2024	NEW	$197,100
														Subtotal = $197,100

Grand Total All Awards = $394,200

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Time course and predictors of progression to postpartum prediabetes and type 2 diabetes in HIV: a prospective longitudinal study of low-income Indian women

Award Number: K23DK136388

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 05/01/2024

PERIOD OF PERFORMANCE END DATE: 02/28/2029

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer