Saturday, July 5, 2025 7/5/2025

The Role of Dietary Nutrients in Chronic Kidney Disease Progression and Apolipoprotein L1 Nephropathy

Award Number: K23DK119542
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 07/15/2020
PERIOD OF PERFORMANCE END DATE: 03/31/2025

Group Awards By:

View Award Description

The Role of Dietary Nutrients in Chronic Kidney Disease Progression and Apolipoprotein L1 Nephropathy - PROJECT SUMMARY/ABSTRACT Chronic kidney disease (CKD) individuals Among malignant Apolipoprotein L1 (APOL1). Approximately 13% of African Americans and 25% of West Africans carry high risk renal genotypes, comprising of any combination of the two APOL1 risk variants, G1 and G2. This re-submission for a National Institute of Diabetes and Digestive Kidney Diseases Patient-Oriented Research Career Development Award (K23) seeks to support Dr. Titilayo Ilori, an Assistant Professor at the Boston University School of Medicine, who wants to build a career focused on mechanistic and interventional studies on the effect of dietary factors and lifestyle on CKD incidence and progression in both low- and adequately-resourced settings, especially in the context of genetic and genomic risk variants. Dr. Ilori's prior research has focused on health disparities in CKD and secondary data analysis of nutrition-related exposures and outcomes in kidney disease. Dr. Ilori intends to extend the scope of her research towards designing prospective studies to study the role of dietary sodium and potassium in CKD progression and APOL1 Nephropathy in Africans. Accordingly, her K23 training is focused on acquiring skills in global health research, nutritional and genetic epidemiology in CKD, statistical genetics and advanced biostatistics skills in longitudinal data analysis, and biomarkers of CKD. We propose a research project that leverages the Human Hereditary and Health in Africa Kidney Disease Research Network and addresses the following research aims: 1) a cross-sectional and prospective examination of the associations of dietary sodium, potassium, and oxalate intake – assessed through 24h urine collections in Africans; 2) a cross-sectional and prospective study to determine the associations of dietary patterns with CKD and CKD progression; 3) diet:gene interaction studies to examine whether dietary factors (sodium, potassium, oxalate, or dietary patterns) modify the effect of association of APOL1 renal genotypes on CKD progression. This is an important project because it may identify if dietary factors are modifiable risk factors for CKD progressions in Africans in SSA, where the cost of dialysis and renal transplantation is prohibitive. Additionally, evidence that diet alters the risk of nephropathy in those with high-risk APOL1 renal risk alleles could be important in investigating new therapeutic targets for APOL1 Nephropathy. is effectively a “death sentence” in Sub-Saharan Africa (SSA) where <2% of with end stage renal disease (ESRD) have access to maintenance dialysis or transplantation. Africans with CKD, there is a faster decline in kidney function and earlier onset of ESRD. This CKD phenotype is largely attributable to variants in the gene encoding


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $185,132 )
2024	2024	BOSTON MEDICAL CENTER CORPORATION	1 BOSTON MEDICAL CTR PL	BOSTON	MA	02118	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	3/18/2024	NON-COMPETING CONTINUATION	$185,132
														Subtotal = $185,132

Issue Date FY: 2023 ( Subtotal = $184,922 )
2023	2023	BOSTON MEDICAL CENTER CORPORATION	1 BOSTON MEDICAL CTR PL STE 1	BOSTON	MA	02118	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	3/14/2023	NON-COMPETING CONTINUATION	$184,922
														Subtotal = $184,922

Issue Date FY: 2022 ( Subtotal = $185,204 )
2022	2022	BOSTON MEDICAL CENTER CORPORATION	1 BOSTON MEDICAL CTR PL STE 1	BOSTON	MA	02118	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	3	5/27/2022	NON-COMPETING CONTINUATION	$0
2022	2022	BOSTON MEDICAL CENTER CORPORATION	1 BOSTON MEDICAL CTR PL STE 1	BOSTON	MA	02118	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	4/12/2022	NON-COMPETING CONTINUATION	$185,204
														Subtotal = $185,204

Issue Date FY: 2021 ( Subtotal = $185,248 )
2021	2021	BOSTON MEDICAL CENTER CORPORATION	1 BOSTON MEDICAL CENTER PL STE 1	BOSTON	MA	02118	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	3/30/2021	NON-COMPETING CONTINUATION	$185,248
														Subtotal = $185,248

Issue Date FY: 2020 ( Subtotal = $187,379 )
2020	2020	BOSTON MEDICAL CENTER CORPORATION	1 BOSTON MEDICAL CENTER PL STE 1	BOSTON	MA	02118	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	7/15/2020	NEW	$187,379
														Subtotal = $187,379

Grand Total All Awards = $927,885

Top

All Categories

About

Search

Reports

Data Submission

Award Information

The Role of Dietary Nutrients in Chronic Kidney Disease Progression and Apolipoprotein L1 Nephropathy

Award Number: K23DK119542

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 07/15/2020

PERIOD OF PERFORMANCE END DATE: 03/31/2025

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer