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Assessment of outcomes and cost-effectiveness in early orthodontic treatment

Award Number: K23DE023824
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 03/30/2020
PERIOD OF PERFORMANCE END DATE: 04/30/2021

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Assessment of outcomes and cost-effectiveness in early orthodontic treatment - DESCRIPTION (provided by applicant): This is an application for a K23 Mentored Research Career Development Award for Dr. James Chen, an Assistant Professor and Orthodontist at UCSF. Dr. Chen is working to establish his research on early interceptive orthodontic treatment for socially disadvantaged children and his clinical expertise. This application is designed to provide the necessary mentoring, training, and research support Dr. Chen needs to become a successful independent investigator. Specifically, this award sets out to accomplish the following goals: (1) become an expert in patient-based early interceptive orthodontic treatment research; (2) to determine the equivalence in treatment outcome and child self-perception between a removable-appliance-based protocol and a fixed-appliance-based protocol; (3) to learn and implement advanced biostatistical methods in clinical research; (4) to learn and implement cost-effectiveness analysis models on early interceptive orthodontic treatment protocols; (5) to develop and grow a strong independent clinical research career; (6) to be a leader in access to orthodontic health care in the United States. In order for Dr. Chen to achieve these goals he will need support to design and implement his study. Dr. Chen has assembled a diverse mentoring team comprised of a primary mentor, Dr. George Taylor, who is the Department Chair of Preventive and Restorative Sciences and conducts public-health-related research on diabetes and periodontitis, and three co-mentors with one consultant: Dr. Greg Huang, Chair of Orthodontics at the University of Washington, who is an expert on evidenced based orthodontic research; Dr. James Kahn, Professor of Clinical Epidemiology in Medicine at UCSF, who is an expert on cost-effectiveness analysis and health care economics; Dr. Jing Cheng, Associate Professor in the School of Dentistry, who is an expert on study design and biostatistical analysis; and Dr. Gerald Nelson, Acting Chair of Division of Orthodontics at UCSF, will serve as a clinical consultant because of his extensive knowledge and experience with early interceptive orthodontic treatment. Oral health disparities and access to orthodontic care for socially disadvantaged children is a major concern in the United States. Dr. Chen's research will focus on critically analyzing a novel removable appliance based treatment protocol aimed at reducing orthodontic need while limiting the financial impact on low-income families compared to the existing fixed appliance based treatment protocol. The hypothesis of this study is that a treatment protocol based on using removable appliances provides the same treatment outcome but better cost-effectiveness than a traditional fixed-appliance protocol. The crux of this study will include comparing the differences in treatment outcome (AIM 1), measured by occlusal index scores (PAR Index and ICON Index), the differences in child self-perception measured by Child Perception Questionnaire (AIM 2) after orthodontic treatment, and the difference in cost-effectiveness (AIM 3) between the removable appliance only group and the fixed appliances only group. For all three aims, Dr. Chen will recruit participants beginning early interceptive orthodontic treatment at La Clinica Community Clinic and UCSF Orthodontic Residency Clinic and he will follow them to completion of their orthodontic treatment and then progression into full permanent dentition. This study will require sophisticated multiple linear regression analyses. This research will be the starting point for developing and initiating a large intervention trial comparing removable based appliance therapy to fixed appliance based therapy for socially disadvantaged children. Towards the end of this K23 award Dr. Chen will prepare and apply for a R34 award to develop the intervention trial followed by an application for an U01 clinical trial award.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$18,078 )
2023	2018	CHILDREN'S HOSPITAL & RESEARCH CENTER AT OAKLAND	747 52ND ST	OAKLAND	CA	94609	ALAMEDA	USA	Oral Diseases and Disorders Research	000	5	10/11/2022	NON-COMPETING CONTINUATION	-$18,078
														Subtotal = -$18,078

Issue Date FY: 2022 ( Subtotal = -$5,047 )
2022	2018	UNIVERSITY OF PACIFIC	3601 PACIFIC AVE	STOCKTON	CA	95211	SAN JOAQUIN	USA	Oral Diseases and Disorders Research	000	6	10/30/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$5,047
														Subtotal = -$5,047

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2018	UNIVERSITY OF PACIFIC	3601 PACIFIC AVE	STOCKTON	CA	95211	SAN JOAQUIN	USA	Oral Diseases and Disorders Research	000	6	10/29/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = -$48,617 )
2020	2018	UNIVERSITY OF PACIFIC	3601 PACIFIC AVE	STOCKTON	CA	95211	SAN JOAQUIN	USA	Oral Diseases and Disorders Research	002	6	7/2/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$48,616
2020	2018	CHILDREN'S HOSPITAL & RESEARCH CENTER AT OAKLAND	747 52ND ST	OAKLAND	CA	94609	ALAMEDA	USA	Oral Diseases and Disorders Research	000	5	5/20/2020	NON-COMPETING CONTINUATION	-$48,617
2020	2018	CHILDREN'S HOSPITAL & RESEARCH CENTER AT OAKLAND	747 52ND ST	OAKLAND	CA	94609	ALAMEDA	USA	Oral Diseases and Disorders Research	001	5	6/3/2020	NON-COMPETING CONTINUATION	$0
2020	2018	CHILDREN'S HOSPITAL & RESEARCH CENTER AT OAKLAND	747 52ND ST	OAKLAND	CA	94609	ALAMEDA	USA	Oral Diseases and Disorders Research	003	5	7/13/2020	NON-COMPETING CONTINUATION	-$48,616
														Subtotal = -$48,617

Issue Date FY: 2018 ( Subtotal = $133,110 )
2018	2018	CHILDREN'S HOSPITAL & RESEARCH CENTER AT OAKLAND	747 52ND ST	OAKLAND	CA	94609	ALAMEDA	USA	Oral Diseases and Disorders Research	000	5	4/30/2018	NON-COMPETING CONTINUATION	$133,110
														Subtotal = $133,110

Issue Date FY: 2017 ( Subtotal = $133,110 )
2017	2017	CHILDREN'S HOSPITAL & RESEARCH CENTER AT OAKLAND	747 52ND ST	OAKLAND	CA	94609	ALAMEDA	USA	Oral Diseases and Disorders Research	000	4	8/18/2017	NON-COMPETING CONTINUATION	$133,110
														Subtotal = $133,110

Issue Date FY: 2016 ( Subtotal = $133,110 )
2016	2016	CHILDRENS HOSP. & RESEARCH CTR OF OAKLAND	747 52ND STREET	OAKLAND	CA	94609	ALAMEDA	USA	Oral Diseases and Disorders Research	000	3	5/26/2016	NON-COMPETING CONTINUATION	$133,110
														Subtotal = $133,110

Issue Date FY: 2015 ( Subtotal = $133,110 )
2015	2015	CHILDRENS HOSP. & RESEARCH CTR OF OAKLAND	747 52ND STREET	OAKLAND	CA	94609	ALAMEDA	USA	Oral Diseases and Disorders Research	001	2	7/17/2015	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$133,110
2015	2013	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Oral Diseases and Disorders Research	000	1	7/16/2015	NEW	$0
														Subtotal = $133,110

Issue Date FY: 2014 ( Subtotal = $0 )
2014	2013	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Oral Diseases and Disorders Research	000	1	7/14/2014	NEW	$0
														Subtotal = $0

Issue Date FY: 2013 ( Subtotal = $133,110 )
2013	2013	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Oral Diseases and Disorders Research	000	1	9/1/2013	NEW	$133,110
														Subtotal = $133,110

Grand Total All Awards = $593,808

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Assessment of outcomes and cost-effectiveness in early orthodontic treatment

Award Number: K23DE023824

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 03/30/2020

PERIOD OF PERFORMANCE END DATE: 04/30/2021

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