Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Early Communication in Tuberous Sclerosis Complex (TSC) and its Prediction of Autism

Award Number: K23DC019440
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 08/01/2022
PERIOD OF PERFORMANCE END DATE: 05/31/2027

Group Awards By:

View Award Description

Early Communication in Tuberous Sclerosis Complex (TSC) and its Prediction of Autism - Project Summary/Abstract Language difficulties have been reported in nearly 70% of people with tuberous sclerosis complex (TSC), but language development is poorly understood in this population. Further, 50% of individuals with TSC develop autism spectrum disorder (ASD); language deficits are also common in ASD. In a preliminary study, we found deficits in early vocal development in most infants with TSC regardless of the diagnosis of ASD. Thus, the goal of our current proposal is to examine potential predictors of language outcome and ASD severity in infants with TSC. In Aim 1, we will code audio-video recordings of infants from TACERN (Tuberous Sclerosis Autism Center of Excellence) for canonical babbling (a precursor to language) and volubility. We will compare canonical babbling and volubility to a non-vocal measure, shared attention, in predicting language outcome and ASD severity at 12 months as measured by the Early Social Communication Scales (ESCS). Aims 2-4 will entail a new longitudinal study of the trajectory of language development and predictors of language outcome and ASD severity. Language will be measured using LENA (Language ENvironment Analysis) recordings (Aim 2); a fast-mapping paradigm (Aim 3) and the MacArthur-Bates Communicative Development Inventories (MCDI) (Aim 3). Shared attention will be measured using the ESCS (Aim 2). Each measure will generate potential predictors of outcome. We will examine how these measures predict language outcome as assessed by the Preschool Language Scale 5 (PLS-5) (Aims 2-3) and autism severity as measured by the Autism Diagnostic Observation Schedule (ADOS) at 36 months (Aim 4). Currently, despite the high risk of language difficulties and ASD in TSC, very little to no data are available about the origin and trajectory of language in TSC and how this might predict outcome. Data generated under this Award will serve as the foundation of an independent research program dedicated to the intersection of TSC neurobiology and language development.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $198,497 )
2026	2026	UNIVERSITY OF TENNESSEE	62 S DUNLAP ST	MEMPHIS	TN	38103	SHELBY	USA	Research Related to Deafness and Communication Disorders	000	5	5/18/2026	NON-COMPETING CONTINUATION	$198,497
														Subtotal = $198,497

Issue Date FY: 2025 ( Subtotal = $197,624 )
2025	2025	UNIVERSITY OF TENNESSEE	62 S DUNLAP ST	MEMPHIS	TN	38103	SHELBY	USA	Research Related to Deafness and Communication Disorders	000	4	5/16/2025	NON-COMPETING CONTINUATION	$197,624
														Subtotal = $197,624

Issue Date FY: 2024 ( Subtotal = $198,500 )
2024	2024	UNIVERSITY OF TENNESSEE	62 S DUNLAP ST	MEMPHIS	TN	38103	SHELBY	USA	Research Related to Deafness and Communication Disorders	000	3	6/5/2024	NON-COMPETING CONTINUATION	$198,500
														Subtotal = $198,500

Issue Date FY: 2023 ( Subtotal = $197,720 )
2023	2023	UNIVERSITY OF TENNESSEE	62 S DUNLAP ST	MEMPHIS	TN	38103	SHELBY	USA	Research Related to Deafness and Communication Disorders	000	2	5/24/2023	NON-COMPETING CONTINUATION	$197,720
														Subtotal = $197,720

Issue Date FY: 2022 ( Subtotal = $200,137 )
2022	2022	UNIVERSITY OF TENNESSEE	62 S DUNLAP STREET STE 103	MEMPHIS	TN	38103	SHELBY	USA	Research Related to Deafness and Communication Disorders	000	1	7/28/2022	NEW	$200,137
														Subtotal = $200,137

Grand Total All Awards = $992,478

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Early Communication in Tuberous Sclerosis Complex (TSC) and its Prediction of Autism

Award Number: K23DC019440

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 08/01/2022

PERIOD OF PERFORMANCE END DATE: 05/31/2027

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer