Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Development and Evaluation of a Post-Emergency Department Buprenorphine Initiation Support Intervention

Award Number: K23DA063970
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 05/01/2026
PERIOD OF PERFORMANCE END DATE: 04/30/2031

Group Awards By:

View Award Description

Development and Evaluation of a Post-Emergency Department Buprenorphine Initiation Support Intervention - Project Summary/Abstract This K23 award will enable Dr. Shastry (principal investigator, PI) to become an independent physician- scientist focused on improving emergency department (ED) care for patients with opioid use disorder (OUD) through the development and evaluation of behavioral and clinical interventions. Opioid overdose deaths continue to exert a significant mortality burden, with over 50,000 deaths in the United States in 2024. Buprenorphine (BUP), a medication for opioid use disorder (OUD), has been shown to decrease opioid overdose mortality and morbidity and can be initiated in the ED. However, BUP adherence and treatment retention is challenging, with high rates of patient attrition, particularly in the first month after ED BUP initiation. The first month after ED BUP initiation is also a uniquely high-risk time with regard to recurrent overdose and mortality. Therefore, there is an essential need to understand barriers to BUP adherence in the first month after ED BUP initiation, and to develop and test behavioral and clinical interventions to address these barriers. During this K23, Dr. Shastry (PI) will: (1) characterize barriers to ED BUP adherence and treatment retention in the first month following ED BUP initiation using mixed-methods; (2) develop and refine a targeted multi- component behavioral and clinical intervention aimed at supporting patients in the first month after ED BUP initiation; and (3) evaluate feasibility, acceptability and preliminary efficacy of this post-ED BUP initiation support intervention through a pilot randomized controlled trial (RCT). To achieve the Specific Aims of her K23 research project, Dr. Shastry (PI) has prepared a research and career development training plan comprised of rigorous mentorship and didactic coursework in mixed-methods research, intervention development and clinical trials. She also has assembled a nationally recognized mentorship team with extensive and renowned content expertise in these areas. Her proposed research and career development plan will enable Dr. Shastry’s (PI) transition to an independent physician-scientist focused on improving ED OUD care through behavioral and clinical interventions. Completion of her K23 research project will provide Dr. Shastry (PI) with crucial preliminary data to estimate the effect size of the novel post-ED BUP initiation support intervention’s efficacy on increasing treatment retention and reducing overdose, informing her subsequent large multi-site R01 RCT evaluating the efficacy of this intervention.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $195,228 )
2026	2026	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Drug Use and Addiction Research Programs	000	1	5/1/2026	NEW	$195,228
														Subtotal = $195,228

Grand Total All Awards = $195,228

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Development and Evaluation of a Post-Emergency Department Buprenorphine Initiation Support Intervention

Award Number: K23DA063970

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 05/01/2026

PERIOD OF PERFORMANCE END DATE: 04/30/2031

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer