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Development and Implementation of a Tobacco and ENDS Use Intervention for Adolescents and Young Adults in the Pediatric Hospital

Award Number: K23DA055736
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 05/15/2022
PERIOD OF PERFORMANCE END DATE: 04/30/2027

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Development and Implementation of a Tobacco and ENDS Use Intervention for Adolescents and Young Adults in the Pediatric Hospital - Project Summary Tobacco use is the single leading cause of preventable death, disability and disease in the United States. Adolescence is a critical developmental period to intervene as 90% of adult tobacco users initiate during this period. Use of electronic nicotine delivery system (ENDS), which are noncombustible tobacco products (e.g., e-cigarettes), has increased dramatically among youth and is associated with numerous adverse health outcomes as well as use of alcohol and other illicit substances. National guidelines recommend counseling to address tobacco use at every adolescent clinical visit; however, many at-risk adolescents do not routinely attend primary care. There are more than 1.5 million adolescent hospitalizations annually and many of these patients are at increased risk for tobacco use and tobacco-related poor health outcomes due to underlying comorbidities (e.g., mental health disorders, substance use disorders, asthma). Although evidence supports treatment of tobacco use during an adult hospitalization, no interventions have been developed or tested in the pediatric hospital setting. Based on promising theoretically-based evidence from the primary care and hospital settings, we propose to design, iteratively refine and assess implementation of a novel tobacco and ENDS use intervention for hospitalized adolescents and young adults (AYAs). We will develop the intervention to treat tobacco and ENDS use in hospitalized AYAs utilizing the 5A’s framework with motivational interviewing, pharmacotherapy and computerized decision support tools. We will iteratively refine the intervention based on key stakeholder feedback, including AYAs, parents/guardians and hospital providers. We will conduct a randomized controlled pilot study (n=144) with 3-month follow up to evaluate preliminary efficacy as well as implementation outcomes (i.e., acceptability, feasibility, fidelity). Through conduct of these formative research activities I will gain critical skills and expertise in the design and preliminary evaluation of behavioral interventions within the context of complex health care systems. We anticipate these findings will directly inform future plans for a hybrid implementation trial of the intervention to determine efficacy for short and long- term ENDS abstinence. This work is significant as it has the potential to increase screening and treatment of tobacco and ENDS use in AYAs leading to decreased rates of use and related poor health outcomes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $196,236 )
2025	2025	CHILDREN'S HOSPITAL LOS ANGELES	4650 W SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Drug Use and Addiction Research Programs	001	4	3/31/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$196,236
2025	2025	CHILDREN'S HOSPITAL LOS ANGELES	4650 W SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Drug Use and Addiction Research Programs	003	4	5/8/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$110,576
2025	2024	CHILDRENS MERCY HOSPITAL	2401 GILLHAM RD	KANSAS CITY	MO	64108	JACKSON	USA	Drug Use and Addiction Research Programs	000	3	3/31/2025	NON-COMPETING CONTINUATION	$0
2025	2024	CHILDRENS MERCY HOSPITAL	2401 GILLHAM RD	KANSAS CITY	MO	64108	JACKSON	USA	Drug Use and Addiction Research Programs	002	3	5/8/2025	NON-COMPETING CONTINUATION	-$110,576
														Subtotal = $196,236

Issue Date FY: 2024 ( Subtotal = $189,540 )
2024	2024	CHILDRENS MERCY HOSPITAL	2401 GILLHAM RD	KANSAS CITY	MO	64108	JACKSON	USA	Drug Use and Addiction Research Programs	000	3	4/17/2024	NON-COMPETING CONTINUATION	$189,540
														Subtotal = $189,540

Issue Date FY: 2023 ( Subtotal = $189,540 )
2023	2023	CHILDRENS MERCY HOSPITAL	2401 GILLHAM RD	KANSAS CITY	MO	64108	JACKSON	USA	Drug Use and Addiction Research Programs	000	2	4/5/2023	NON-COMPETING CONTINUATION	$189,540
														Subtotal = $189,540

Issue Date FY: 2022 ( Subtotal = $189,540 )
2022	2022	CHILDREN'S MERCY HOSPITAL, THE	2401 GILLHAM RD	KANSAS CITY	MO	64108	JACKSON	USA	Drug Use and Addiction Research Programs	000	1	5/12/2022	NEW	$189,540
														Subtotal = $189,540

Grand Total All Awards = $764,856

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Development and Implementation of a Tobacco and ENDS Use Intervention for Adolescents and Young Adults in the Pediatric Hospital

Award Number: K23DA055736

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 05/15/2022

PERIOD OF PERFORMANCE END DATE: 04/30/2027

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