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EFFECTS OF NICOTINE IN SMOKERS WITH ANXIOUS MOOD

Award Number: K23DA016376
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 09/25/2003
PERIOD OF PERFORMANCE END DATE: 07/31/2011

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EFFECTS OF NICOTINE IN SMOKERS WITH ANXIOUS MOOD - DESCRIPTION (provided by applicant): This request for a Mentored Patient-Oriented Research Career Development Award (K23) is made by Dr. Sandra Baker-Morissette to foster her academic and research career development as a clinical scientist in smoking, nicotine dependence and psychiatric comorbidity. Dr. Baker-Morissette's career development plan spans 5 years, during which she will continue to work closely with her sponsor, Dr. Gulliver, as well as her co-mentors, Drs. David Barlow, David Spiegel, and Stephen Tiffany. Statistical consultation will be provided by the Boston University School of Medicine. Her career plan includes individual meetings with each mentor, mentorship team meetings, and coursework in statistical analysis and ethics. Her short-term goals are to expand upon her theoretical, methodological, and statistical skills needed to become a highly productive clinical scientist and to develop an independent programmatic line of research. Dr. Baker-Morissette's plan should yield sufficient experience as defined by data collection, grant writing, and paper presentations to advance by the close of the award to Associate Professor. Dr. Baker-Morissette's overarching ambition is to make a meaningful contribution to the knowledge base on tobacco use and comorbid anxiety disorders across the lifespan. Her personal career goal is to progress to Full Professor within the Medical School of Boston University. The proposed study expands on Dr. Baker-Morissette's initial studies of anxiety and tobacco use research by examining the effects of nicotine and mood cue exposure on smoking urge and anxiety in cigarette smokers who have comorbid anxiety disorders. In a between- and within-subjects design, smokers will receive a nicotine (21 mg) or placebo patch in a counterbalanced order across two assessment days. During each assessment day, they will engage in a series of imaginal cue exposures that vary in content: smoking plus anxiety cues, smoking cues alone, anxiety cues alone, and neutral cues. Participants will complete self-report questionnaires prior to and following each exposure, including measures of smoking urge and anxiety. Understanding the effects of nicotine on smoking urge in a psychiatric population is particularly important in light of the difficulty that smokers with psychiatric comorbidity have with quitting smoking. Knowledge of such factors may assist our understanding of conditions that influence the relapse process, as well as the effect of certain cues on smoking urge when individuals are attempting to quit smoking and simultaneously using transdermal nicotine replacement therapy. In sum, this research will foster the career development of Dr. Baker- Morissette, and ensure the next step of her programmatic research, which has an excellent probabilit3-to increase our understanding of the links between nicotine, negative affect and tobacco use disorder.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2010 ( Subtotal = -$1 )
2010	2007	TEXAS A & M RESEARCH FOUNDATION	400 Harvey Mitchell Parkway S,	COLLEGE STATION	TX	77845	BRAZOS	USA	Drug Abuse Scientist Development Awards, Research Scientist Development Awards, and Research Scientist Awards	003	6	4/12/2010	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$10,844
2010	2007	TEXAS A & M RESEARCH FOUNDATION	400 Harvey Mitchell Parkway S,	COLLEGE STATION	TX	77845	BRAZOS	USA	Drug Abuse Scientist Development Awards, Research Scientist Development Awards, and Research Scientist Awards	002	6	10/28/2009	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$69,650
2010	2007	BOSTON UNIVERSITY	25 BUICK ST	BOSTON	MA	02215	SUFFOLK	USA	Drug Abuse Scientist Development Awards, Research Scientist Development Awards, and Research Scientist Awards	001	5	10/23/2009	NON-COMPETING CONTINUATION	-$69,651
2010	2007	BOSTON UNIVERSITY	25 BUICK ST	BOSTON	MA	02215	SUFFOLK	USA	Drug Abuse Scientist Development Awards, Research Scientist Development Awards, and Research Scientist Awards	004	5	4/12/2010	NON-COMPETING CONTINUATION	$10,844
2010	2007	TEXAS A & M RESEARCH FOUNDATION	400 Harvey Mitchell Parkway S,	COLLEGE STATION	TX	77845	BRAZOS	USA	Drug Abuse Scientist Development Awards, Research Scientist Development Awards, and Research Scientist Awards	005	6	8/4/2010	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2010	2003	BOSTON UNIVERSITY	25 BUICK STREET	BOSTON	MA	02215	SUFFOLK	USA	Drug Abuse Scientist Development Awards, Research Scientist Development Awards, and Research Scientist Awards	000	1	10/23/2009	NEW	$0
														Subtotal = -$1

Issue Date FY: 2007 ( Subtotal = $136,817 )
2007	2007	BOSTON UNIVERSITY	25 BUICK STREET	BOSTON	MA	02215	SUFFOLK	USA	Drug Abuse Scientist Development Awards, Research Scientist Development Awards, and Research Scientist Awards	000	5	6/26/2007	NON-COMPETING CONTINUATION	$136,817
														Subtotal = $136,817

Issue Date FY: 2006 ( Subtotal = $133,776 )
2006	2006	BOSTON UNIVERSITY	25 BUICK STREET	BOSTON	MA	02215	SUFFOLK	USA	Drug Abuse Scientist Development Awards, Research Scientist Development Awards, and Research Scientist Awards	000	4	6/23/2006	NON-COMPETING CONTINUATION	$133,776
														Subtotal = $133,776

Issue Date FY: 2005 ( Subtotal = $130,707 )
2005	2005	BOSTON UNIVERSITY	25 BUICK STREET	BOSTON	MA	02215	SUFFOLK	USA	Drug Abuse Scientist Development Awards, Research Scientist Development Awards, and Research Scientist Awards	000	3	6/30/2005	NON-COMPETING CONTINUATION	$130,707
														Subtotal = $130,707

Issue Date FY: 2004 ( Subtotal = $127,756 )
2004	2004	BOSTON UNIVERSITY	25 BUICK STREET	BOSTON	MA	02215	SUFFOLK	USA	Drug Abuse Scientist Development Awards, Research Scientist Development Awards, and Research Scientist Awards	000	2	7/1/2004	NON-COMPETING CONTINUATION	$127,756
														Subtotal = $127,756

Issue Date FY: 2003 ( Subtotal = $123,412 )
2003	2003	BOSTON UNIVERSITY	25 BUICK STREET	BOSTON	MA	02215	SUFFOLK	USA	Drug Abuse Scientist Development Awards, Research Scientist Development Awards, and Research Scientist Awards	000	1	9/26/2003	NEW	$123,412
														Subtotal = $123,412

Grand Total All Awards = $652,467

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EFFECTS OF NICOTINE IN SMOKERS WITH ANXIOUS MOOD

Award Number: K23DA016376

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 09/25/2003

PERIOD OF PERFORMANCE END DATE: 07/31/2011

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