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Optimizing Mindfulness Practice for Pain in People with Multiple Sclerosis

Award Number: K23AT013270
ORGANIZATION: CENTER FOR DRUG EVALUATION AND RESEARCH, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 04/15/2026
PERIOD OF PERFORMANCE END DATE: 03/31/2031

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Optimizing Mindfulness Practice for Pain in People with Multiple Sclerosis - Project Summary/Abstract Chronic pain affects a large portion of people with multiple sclerosis (PwMS), impacting their daily activities and overall quality of life. Mindfulness-Based Cognitive Therapy (MBCT) has shown effectiveness in alleviating pain for people with MS; however, there is considerable variation in how individuals respond to treatment. Consistent home practice is hypothesized to be a key factor in producing therapeutic outcomes. However, mastering a new skill in treatment does not necessarily mean that it will translate to real-life situations, and a consistent barrier to treatment success occurs when individuals fail to practice mindfulness in daily life. As a result, there is a significant need to identify barriers and facilitators to mindfulness practice among people with MS undergoing MBCT for chronic pain. Recent advances in mobile technology allow investigators to examine these barriers in close to real time and provide adaptive and timely intervention. This K23 Career Development Award will provide the candidate training in intensive longitudinal and micro-randomized trial design and analysis, acquire proficiency in just-in-time adaptive intervention (JITAI) development, and enhance grantsmanship and scientific dissemination skills with a focus on developing a successful R01 application utilizing pilot data from this project. This new training will be leveraged to advance understanding and engagement in mindfulness practice among individuals with MS participating in MBCT for chronic pain in three integrated steps. Aim 1 will utilize ecological momentary assessment (EMA) to identify barriers and facilitators to mindfulness practice among 80 individuals with MS during 8-weeks of MBCT. Aim 2 will develop a JITAI informed by the EMA data to deliver personalized “nudges” promoting mindfulness practice during MBCT sessions. This phase will also incorporate human-centered design methods and feedback from PwMS to maximize feasibility. Aim 3 will use micro-randomized trial methodology (MRT) to optimize JITAI components and explore preliminary feasibility for 50 people with MS participating in MBCT. All aims will be supported by didactic, experiential, and mentored training in the fundamentals of clinical research through the Department of Rehabilitation Medicine at the University of Washington School of Medicine. Collectively the research and training aims of this project seek to inform and personalize the delivery of mindfulness-based interventions (MBIs) for chronic pain not only in people with MS but also in other populations experiencing pain. This award will equip the candidate with the expertise to independently lead innovative research in MBIs, advance pain management strategies and enhance quality of life for individuals with chronic health conditions.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $164,268 )
2026	2026	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Research and Training in Complementary and Integrative Health	000	1	4/15/2026	NEW	$164,268
														Subtotal = $164,268

Grand Total All Awards = $164,268

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Optimizing Mindfulness Practice for Pain in People with Multiple Sclerosis

Award Number: K23AT013270

ORGANIZATION: CENTER FOR DRUG EVALUATION AND RESEARCH, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 04/15/2026

PERIOD OF PERFORMANCE END DATE: 03/31/2031

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