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Digital Mindfulness Meditation-enhanced Cognitive Behavioral Therapy (CBT-MM) for Binge Eating Disorder

Award Number: K23AT012126
ORGANIZATION: CENTER FOR DRUG EVALUATION AND RESEARCH, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 04/01/2023
PERIOD OF PERFORMANCE END DATE: 03/31/2028

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Digital Mindfulness Meditation-enhanced Cognitive Behavioral Therapy (CBT-MM) for Binge Eating Disorder - PROJECT SUMMARY/ABSTRACT Binge eating disorder (BED) is a prevalent disorder, affecting 3.5% of Americans. BED is maintained by two- pathways: (1) dietary over-restriction and (2) emotion dysregulation. Current treatments for BED, such as Cognitive Behavioral Therapy (CBT) produce suboptimal results because they only target over-restriction. Mindfulness meditation (MM) targets emotion dysregulation and could thus be an important addition to CBT for Eating Disorders. Furthermore, digital delivery of an MMT for BED would offer unprecedented scalability, but there are no current digital MMTs for BED. The current K23 proposal involves developing a digital Mindfulness Meditation-enhanced Cognitive Behavioral Therapy (CBT-MM) for BED via two phases. CBT-MM will target the two different mechanisms of BED (dietary over-restriction and emotion dysregulation). In Phase 1, I will finalize the development of digital CBT-MM via interview-based user testing. In Phase 2, I will conduct a pilot feasibility randomized controlled trial (RCT). For the RCT, 40 individuals with BED recruited nationally will be randomized to digital: 1) CBT-MM (n = 20); or 2) an already developed digital CBT treatment (iTakeControl) only (n = 20). The RCT will be conducted virtually, with video-based assessments at baseline, mid- and post-treatment, and 3-month follow up. Aim 1 is to develop digital CBT-MM. Aim 2 is to evaluate feasibility and acceptability. Aim 3 is to measure within-group changes from pre-to post treatment on binge eating remission, binge eating frequency, weight, quality of life, depressive symptoms, emotion dysregulation, dietary over-restriction, and trait mindfulness. This project has the potential for developing an innovative, theory-driven, efficacious, and scalable mindfulness-based treatment for BED that can have a large public health impact. To carry out this K23, I will receive mentorship from a leading team of experts in the areas of mindfulness, CBT for eating disorders, technology-based treatment development, and qualitative methods. This K23 will specifically facilitate my training in: (1) developing and refining mindfulness-based eating and weight disorder treatments; (2) technology-based treatment development, (3) formalized training in conducting clinical trials, and (4) qualitative methods for intervention development. This award will serve as a launching point for my career as I leverage the training and research skills afforded by this award to become a leader in the field of digital mindfulness-based treatment development for eating and weight disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $153,448 )
2026	2026	YESHIVA UNIVERSITY	500 W 185TH ST	NEW YORK	NY	10033	NEW YORK	USA	Research and Training in Complementary and Integrative Health	000	4	3/24/2026	NON-COMPETING CONTINUATION	$153,448
														Subtotal = $153,448

Issue Date FY: 2025 ( Subtotal = $154,002 )
2025	2025	YESHIVA UNIVERSITY	500 W 185TH ST	NEW YORK	NY	10033	NEW YORK	USA	Research and Training in Complementary and Integrative Health	000	3	3/14/2025	NON-COMPETING CONTINUATION	$154,002
														Subtotal = $154,002

Issue Date FY: 2024 ( Subtotal = $153,923 )
2024	2024	YESHIVA UNIVERSITY	500 W 185TH ST	NEW YORK	NY	10033	NEW YORK	USA	Research and Training in Complementary and Integrative Health	000	2	4/19/2024	NON-COMPETING CONTINUATION	$153,923
														Subtotal = $153,923

Issue Date FY: 2023 ( Subtotal = $154,060 )
2023	2023	YESHIVA UNIVERSITY	500 W 185TH ST	NEW YORK	NY	10033	NEW YORK	USA	Research and Training in Complementary and Integrative Health	000	1	3/23/2023	NEW	$154,060
														Subtotal = $154,060

Grand Total All Awards = $615,433

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Digital Mindfulness Meditation-enhanced Cognitive Behavioral Therapy (CBT-MM) for Binge Eating Disorder

Award Number: K23AT012126

ORGANIZATION: CENTER FOR DRUG EVALUATION AND RESEARCH, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 04/01/2023

PERIOD OF PERFORMANCE END DATE: 03/31/2028

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