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Real time biofeedback Tai Chi training for knee osteoarthritis: A feasibility study

Award Number: K23AT009568
ORGANIZATION: CENTER FOR DRUG EVALUATION AND RESEARCH, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 08/15/2018
PERIOD OF PERFORMANCE END DATE: 07/31/2024

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Real time biofeedback Tai Chi training for knee osteoarthritis: A feasibility study - Program Director/Principal Investigator (Liu, Wei): Abstract The overall goal of this mentored career development award (K23) is to support Wei Liu, PhD to become an independent investigator in the field of complementary and alternative medicine (CAM) and chronic pain, with a focus on biofeedback Tai Chi intervention development and testing. Disabilities that arise from typical impairments of knee osteoarthritis (OA) include decreased muscle strength, reduced range of motion, and decreased aerobic cardiovascular function. A large number of individuals with knee OA experience disability and require rehabilitation. Traditional Tai Chi intervention (TC) has been promising therapeutic intervention for pain reduction in knee OA, but the efficacy of TC as a knee OA intervention have proven inconclusive because individual with knee OA performed TC with widely varying mechanical knee joint loads, this variation could be a confounding factor in any study of TC. Therefore, Dr. Liu proposes a feasibility study in Aim 1 to quantify external knee adduction moment (EKAM), a strong predictor of OA disease severity and progression during TC practice, and in Aim 2, he will introduce real time biofeedback Tai Chi training (BTC) and see if it is feasible to use biofeedback of torque acting on the knee to modify some TC forms by reducing EKAM. In Aim 3, he will conduct a pilot study to determine the feasibility of using optimized BTC training for OA knee pain reduction. The proposed research represents the first study to identify the biomechanical mechanisms of TC exercise (Aim 1 and 2) and target EKAM by using real-time biofeedback approach and manipulate EKAM independently for TC intervention (Aim 3). We can alter medial knee joint loading response of TC. EKAM would be a biomechanical marker for TC intervention associated with clinical outcomes in knee OA. At the completion of the pilot trial in Aim 3, the optimized BTC intervention will be ready to be tested in an R33 to evaluate its efficacy. This proposal represents a 5-year comprehensive mentoring, training and research plan to transition the candidate, Dr. Liu, to a career as a successful independent investigator. By end of the award period, Dr. Liu will have contributed substantially to the field of CAM research. Already an expert on biomechanical approaches to Tai Chi, he will be positioned to become a leader in developing and testing novel CAM interventions in this area, including conducting behavioural clinical trials. OMB No. 0925-0001/0002 (Rev. 03/16 Approved Through 10/31/2018) Page Continuation Format Page


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$1,665 )
2025	2022	THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Research and Training in Complementary and Integrative Health	000	5	12/10/2024	NON-COMPETING CONTINUATION	-$1,665
														Subtotal = -$1,665

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2020	EDWARD VIA VIRGINIA COLLEGE OF OSTEOPATHIC MEDICINE	2265 KRAFT DR	BLACKSBURG	VA	24060	MONTGOMERY	USA	Research and Training in Complementary and Integrative Health	000	3	11/23/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $164,840 )
2022	2022	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Research and Training in Complementary and Integrative Health	002	5	7/28/2022	NON-COMPETING CONTINUATION	$164,840
2022	2021	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Research and Training in Complementary and Integrative Health	001	4	5/2/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$135,345
2022	2020	EDWARD VIA VIRGINIA COLLEGE OF OSTEOPATHIC MEDICINE	2265 KRAFT DR	BLACKSBURG	VA	24060	MONTGOMERY	USA	Research and Training in Complementary and Integrative Health	000	3	5/2/2022	NON-COMPETING CONTINUATION	-$135,345
														Subtotal = $164,840

Issue Date FY: 2021 ( Subtotal = $164,840 )
2021	2021	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Research and Training in Complementary and Integrative Health	001	4	8/11/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$164,840
2021	2020	EDWARD VIA VIRGINIA COLLEGE OF OSTEOPATHIC MEDICINE	2265 KRAFT DR	BLACKSBURG	VA	24060	MONTGOMERY	USA	Research and Training in Complementary and Integrative Health	000	3	8/10/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $164,840

Issue Date FY: 2020 ( Subtotal = $164,840 )
2020	2020	EDWARD VIA VIRGINIA COLLEGE OF OSTEOPATHIC MEDICINE	2265 KRAFT DR	BLACKSBURG	VA	24060	MONTGOMERY	USA	Research and Training in Complementary and Integrative Health	000	3	7/23/2020	NON-COMPETING CONTINUATION	$164,840
														Subtotal = $164,840

Issue Date FY: 2019 ( Subtotal = $164,840 )
2019	2019	EDWARD VIA VIRGINIA COLLEGE OF OSTEOPATHIC MEDICINE	2265 KRAFT DR	BLACKSBURG	VA	24060	MONTGOMERY	USA	Research and Training in Complementary and Integrative Health	000	2	7/11/2019	NON-COMPETING CONTINUATION	$164,840
														Subtotal = $164,840

Issue Date FY: 2018 ( Subtotal = $164,840 )
2018	2018	EDWARD VIA VIRGINIA COLLEGE OF OSTEOPATHIC MEDICINE	2265 KRAFT DR	BLACKSBURG	VA	24060	MONTGOMERY	USA	Research and Training in Complementary and Integrative Health	000	1	8/9/2018	NEW	$164,840
														Subtotal = $164,840

Grand Total All Awards = $822,535

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Real time biofeedback Tai Chi training for knee osteoarthritis: A feasibility study

Award Number: K23AT009568

ORGANIZATION: CENTER FOR DRUG EVALUATION AND RESEARCH, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 08/15/2018

PERIOD OF PERFORMANCE END DATE: 07/31/2024

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