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Addressing Cross-Cultural Adaptation of Patient Reported Outcome Measures for Distal Radius Fractures

Award Number: K23AR082960
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 04/01/2024
PERIOD OF PERFORMANCE END DATE: 03/31/2029

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Addressing Cross-Cultural Adaptation of Patient Reported Outcome Measures for Distal Radius Fractures - PROJECT SUMMARY: Distal radius fractures are one of the most commonly occurring fractures and represent a great morbidity burden in the United States and worldwide. Patient reported outcome measures (PROMs) that assess patients’ physical function are the standard for assessing treatment outcomes and can help inform treatment decisions for patients with distal radius fractures. Notably, however, PROMs must be linguistically and culturally relevant to appropriately measure physical function and inform care. There are currently no appropriately culturally adapted PROMs to assess the physical function of Spanish-speaking patients with distal radius fractures. As PROM scores affect care decisions, mismeasurement from the lack of cultural adaptation can affect clinical care and patient outcomes. The development and validation of culturally adapted PROMs for Spanish- speaking patients with distal radius fractures will yield new knowledge about gaps in the cultural adaptation of linguistically translated PROMs and provide the foundation for future R01 proposals to study the impact of cross-culturally adapted PROMs on measuring physical function, subsequent treatment decisions, and outcomes for patients with distal radius fractures and other orthopaedic injuries. By including patients from two countries, we can assess the impact of culture on outcome measurement which may be generalizable to patients in the United States and worldwide. This K23 Award will provide Dr. Shapiro focused training and mentorship in three critical areas: 1) conducting psychometric evaluations of PROMs using mixed-methods research designs, 2) understanding the cultural and linguistic influence on health and outcome measurement, and 3) conducting trials of outcomes measurement tools in diverse populations. Dr. Shapiro has assembled a team of mentors that includes: Dr. Patricia Katz (Professor Dept. of Medicine, UCSF), Dr. Alicia Fernandez (Professor Dept. of Medicine and Associate Dean, UCSF), Dr. Theodore Miclau (Professor Dept. of Orthopaedic Surgery and Vice Chair, UCSF). This is supplemented by a team of expert advisors and domestic and international collaborators. We aim to 1) assess the content validity of the Patient-Reported Outcomes Measurement Information System – Physical Function (PROMIS-PF) for measuring physical function in Spanish-speaking patients, 2) adapt the PROMIS-PF for two Spanish-speaking populations with distal radius fractures, and 3) validate and pilot test the new culturally-adapted PROMIS-PF tools. This will be the first study to evaluate the impact of culture on PROM items and to subsequently cross-culturally adapt, validate, and pilot test cross-culturally adapted PROMs using mixed-methods design for two Spanish-speaking populations. The new PROMs can serve as the foundation for future R01 proposals to study the impact of cross-culturally adapted PROMs on treatment decisions and outcomes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $167,972 )
2026	2026	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	3	5/1/2026	NON-COMPETING CONTINUATION	$167,972
														Subtotal = $167,972

Issue Date FY: 2025 ( Subtotal = $168,140 )
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	3/27/2025	NON-COMPETING CONTINUATION	$168,140
														Subtotal = $168,140

Issue Date FY: 2024 ( Subtotal = $168,212 )
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	4/1/2024	NEW	$168,212
														Subtotal = $168,212

Grand Total All Awards = $504,324

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Addressing Cross-Cultural Adaptation of Patient Reported Outcome Measures for Distal Radius Fractures

Award Number: K23AR082960

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 04/01/2024

PERIOD OF PERFORMANCE END DATE: 03/31/2029

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