ABSTRACT
Dr. Fei Li Kuang is an Assistant Professor in the Division of Allergy and Immunology at Northwestern
University Feinberg School of Medicine. Her clinical and research interests focus on eosinophilic disorders,
including eosinophilic gastrointestinal disorders (EGIDs), inflammatory diseases defined by excessive
numbers of GI tissue eosinophils as result of an inappropriate prolonged Th2 response to food antigens.
Both eosinophilic esophagitis (EoE) and non-esophageal EGIDs such as eosinophilic gastritis/duodenitis
(EG/EoD) are associated with significant morbidity and have a profoundly negative impact on quality of life.
When untreated, there is progressive scarring of the affected GI tract segments that is not easily reversible.
While both eosinophils and specialized Th2 cells are implicated in EGID pathogenesis, numerous
questions remain as to their precise roles. This application proposes to focus on what is different about
eosinophils in EGID as compared to myriad number of other eosinophilic disorders accompanied by
excessive blood eosinophilia. Similarly, specialized Th2 cells are invoked to be biomarkers of disease in
IgE-mediated disorders such as food allergy and allergic rhino-conjunctivitis, which are markedly different
allergic diseases from EGID, so what makes these cells different in EGID will also be examined.
This career development award, under the mentorship of Dr. Bruce Bochner, focuses on investigating the
cellular and molecular mechanisms of EGID pathogenesis. to advance the understanding of this disease
process. Dr. Kuang has preliminary evidence suggesting that there are unique blood eosinophil signatures
in EGIDs that distinguish them from blood eosinophils in other eosinophilic disorders, and that specialized
circulating Th2 cells in EGIDs differ from those identified in more traditional IgE-mediated atopic conditions,
and that quantitative and qualitative changes in both cell types track with response to therapy and disease
remission. The central hypothesis of this proposal is that unique blood eosinophil and T lymphocyte
signatures define EGID as a clinical entity distinct from other eosinophilic disorders or food-
triggered diseases. This will be addressed by 3 non-overlapping but complementary aims: 1) Definition
of unique blood eosinophil signatures in EGID that distinguish it from other eosinophil-associated
disorders or atopic disorders with blood eosinophilia; 2) Precise identification of the specialized Th2 cells
in EGID as compared to food allergy; 3) Evaluation of the effect of dietary and steroid treatment on blood
eosinophil and specialized Th2 lymphocyte signatures in EGID
This innovative study will use novel data generated by Dr. Kuang to further investigate areas of EGID that
are currently poorly understood. Importantly, this award will provide Dr. Kuang with additional career
development and training needed to build her own successful research team, establish independence from
her mentor and significantly advance her career studying EGID pathogenesis.