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HIV in Injury: eValuation of Self-Testing in African Emergency Care for the Injured (HIV AECI)

Award Number: K23AI145411
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 03/06/2020
PERIOD OF PERFORMANCE END DATE: 11/30/2025

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HIV in Injury: eValuation of Self-Testing in African Emergency Care for the Injured (HIV AECI) - PROJECT SUMMARY HIV and injury are substantial public health problems, which disproportionately occur in low-and middle-income countries (LMICs); with the majority of morbidity and mortality levied in sub-Saharan Africa (SSA), in countries such as Kenya. Although HIV and injury are immense problems, there is a paucity of study of their intersection. Additionally, those most likely to need emergent injury care are young adults and males, key groups for HIV services that have not been adequately engaged in HIV programs in SSA. This epidemiologic concordance of injury in neglected HIV groups represents an opportunity to increase testing during the provision of commonly sought emergency care; a known period for personal health growth in young adults. However, as facility based opt-out HIV testing has been challenging in SSA, and Kenya specifically, novel approaches to improve testing among populations with unique needs are required. HIV self-testing (HIVST) is an innovative strategy, which is endorsed by the Kenyan Ministry of Health as a method to increase HIV care among high-risk groups, such as young adults and males, but has never been leveraged in SSA emergency care to enhance HIV testing. This research aims to address knowledge gaps in the study of HIV and emergency injury care in Kenya. The proposed work will generate robust quantitative and qualitative data on characteristics of emergency department (ED) HIV care as well as barriers and opportunities to care, and the use of HIVST to augment testing in the difficult to access young adult and male populations seeking treatments. Subsequently, implementation science using a hybrid implementation-effectiveness design, which has not been employed prior in SSA acute care research, will be used to efficiently evaluate the innovative delivery of ED based HIVST among patients and providers. These studies will provide crucial foundational data for future large-scale multi- site implementation trials which will inform global policy on the interface of HIV and emergency care in SSA as well as the use HIVST to enhance care delivery in previously missed LMIC populations (i.e. young males). My long-term career goal is to become a highly trained clinician scientist with expertise in implementation research and the study of the intersection of HIV and emergency care in LMICs. With the attainment of training and mentorship through this K23 award, in conjunction with my prior HIV and emergency care research experiences; I will be able to succeed in that trajectory. My career development aims for this proposal are to gain in-depth training in implementation science and mixed methods research while generating innovative data at the intersection of HIV, emergency care and ED-HIVST. Activities from this proposal will facilitate my transition to being an independent investigator able to design and lead future research studies that will evaluate the impacts of HIVST and additional ED interventions on testing and linkage to care of index patients and social / sexual contacts using implementation science trials, complemented by qualitative methods, to contribute to informing and improving HIV programming in high-risk LMIC populations.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2024	RHODE ISLAND HOSPITAL	593 EDDY ST	PROVIDENCE	RI	02903	PROVIDENCE	USA	Allergy and Infectious Diseases Research	000	5	4/2/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $196,992 )
2024	2024	RHODE ISLAND HOSPITAL	593 EDDY ST	PROVIDENCE	RI	02903	PROVIDENCE	USA	Allergy and Infectious Diseases Research	000	5	2/21/2024	NON-COMPETING CONTINUATION	$196,992
														Subtotal = $196,992

Issue Date FY: 2023 ( Subtotal = $196,804 )
2023	2023	RHODE ISLAND HOSPITAL	593 EDDY ST	PROVIDENCE	RI	02903	PROVIDENCE	USA	Allergy and Infectious Diseases Research	000	4	2/8/2023	NON-COMPETING CONTINUATION	$196,804
														Subtotal = $196,804

Issue Date FY: 2022 ( Subtotal = $185,122 )
2022	2022	RHODE ISLAND HOSPITAL	593 EDDY ST	PROVIDENCE	RI	02903	PROVIDENCE	USA	Allergy and Infectious Diseases Research	000	3	2/9/2022	NON-COMPETING CONTINUATION	$185,122
														Subtotal = $185,122

Issue Date FY: 2021 ( Subtotal = $196,378 )
2021	2021	RHODE ISLAND HOSPITAL	593 EDDY ST	PROVIDENCE	RI	02903	PROVIDENCE	USA	Allergy and Infectious Diseases Research	000	2	2/18/2021	NON-COMPETING CONTINUATION	$196,378
														Subtotal = $196,378

Issue Date FY: 2020 ( Subtotal = $198,279 )
2020	2020	RHODE ISLAND HOSPITAL	593 EDDY ST	PROVIDENCE	RI	02903	PROVIDENCE	USA	Allergy and Infectious Diseases Research	000	1	3/6/2020	NEW	$198,279
														Subtotal = $198,279

Grand Total All Awards = $973,575

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HIV in Injury: eValuation of Self-Testing in African Emergency Care for the Injured (HIV AECI)

Award Number: K23AI145411

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 03/06/2020

PERIOD OF PERFORMANCE END DATE: 11/30/2025

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