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Gray matter microstructure, a sleep-related marker of preclincal Alzheimer's disease

Award Number: K23AG097998
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 07/01/2026
PERIOD OF PERFORMANCE END DATE: 04/30/2031

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Gray matter microstructure, a sleep-related marker of preclincal Alzheimer's disease - PROJECT SUMMARY (ABSTRACT) This project is a Mentored Patient-Oriented Research Career Development (K23) Award with both research and career-development training components. The Candidate, a clinical sleep neurologist, has the overarching career goal of (1) identifying mechanistic markers that are essential to preclinical Alzheimer’s disease pathogenesis, and (2) determining how sleep physiology contributes to mechanistic markers of Alzheimer’s disease pathogenesis. Training provided via this K23 project has been thoughtfully designed to help the Candidate develop into an independent clinical scientist. The training framework includes mentorship, structured coursework, mentored research, and a robust team of expert advisors that will fill vital gaps in his scientific education and guide his professional development. Training will cover the areas of clinical and translational science, Alzheimer’s disease pathology, the implementation of amyloid/tau/neurodegeneration markers in research, and the implementation of sleep actigraphy and electroencephalography (EEG) in Alzheimer’s disease research. Research Specific Aims (1 and 2) proposed in this K23 project will leverage HCHS/SOL to test the hypotheses that (1) lower brain gray matter microstructure integrity is a marker of preclinical Alzheimer’s disease; and (2) gray matter microstructure mediates a relationship between modifiable sleep patterns and preclinical Alzheimer's disease progression in adults. This K23 project will also pilot in-home portable forehead EEG (Specific Aim 3) as a more ecologically valid alternative to gold-standard in-lab polysomnography (PSG) for measuring sleep physiology. The training and research within this K23 will position the Candidate to submit an NIH Research Project (R01) Grant application that implements in-home portable EEG in a subsequent large scale observational study. As sleep physiology is plausibly the mechanistic underpinning that mediates the relationship between sleep patterns and preclinical Alzheimer’s disease progression, the implementation of portable EEG in a subsequent longitudinal observational study of adults may decipher the specific features of sleep physiology that contribute to gray matter microstructure decline and Alzheimer’s disease risk. As sleep behaviors are highly modifiable and influenced by culture, this K23 (and subsequent R01) project may help uncover specific sleep physiology targets for personalized interventions that help preserve gray matter microstructure and prevent Alzheimer’s disease in all people.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $145,706 )
2026	2026	UNIVERSITY OF MIAMI	1320 S DIXIE HWY STE 1200	CORAL GABLES	FL	33146	MIAMI-DADE	USA	Aging Research	000	1	7/1/2026	NEW	$145,706
														Subtotal = $145,706

Grand Total All Awards = $145,706

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Gray matter microstructure, a sleep-related marker of preclincal Alzheimer's disease

Award Number: K23AG097998

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 07/01/2026

PERIOD OF PERFORMANCE END DATE: 04/30/2031

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