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The Brain Health of Middle Aged and Older Adults Who May Use Hormone Therapy: An Examination of Alzheimer’s Disease and Related Dementias Risk and Psychosocial Stressors

Award Number: K23AG084851
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 12/01/2023
PERIOD OF PERFORMANCE END DATE: 11/30/2028

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The Brain Health of Middle Aged and Older Adults Who May Use Hormone Therapy: An Examination of Alzheimer’s Disease and Related Dementias Risk and Psychosocial Stressors - Alzheimer’s disease and related dementias (ADRD) is a public health priority and is well-established as a health concern. Yet, little is known about the epidemiology of and risk factors for ADRD among adults from under-resourced communities, including individuals who use male or female hormones. Most existing ADRD research was not designed to identify participants from these communities or assess how ADRD risk is affected by psychosocial stressors (e.g., stress-induced conditions, negative public attitudes, social rejection and isolation, economic instability). It is also unclear if ADRD prevalence and risk vary by under-resourced community subgroups (e.g., natal females, natal males) or among those using hormone replacement therapy. The overarching goal of this K23 Mentored Patient-Oriented Research Career Development Award is to provide the applicant with the skills necessary to become an independent researcher and a leader in ADRD and cognitive aging among middle aged and older adults from under-resourced communities. Specific training goals include: 1) Develop proficiency in advanced statistical methods for the analysis of longitudinal data; 2) Enhance skills in qualitative and mixed methods research, 3) Cultivate a more nuanced understanding of key influences on ADRD and cognitive function among adults from under-resourced communities and obtain training in cognitive function assessment; and 4) Build expertise in community-engaged research that equitably and meaningfully involves community members throughout the research process. The research proposed in this K23 will first examine the epidemiology of ADRD among middle aged and older adults from under resourced communities, including those receiving hormone replacement therapy, using Kaiser Permanente electronic health record (EHR) data from the ongoing STRONG study (R01AG066956, PI: Goodman). To enhance our knowledge about ADRD risk among adults from under-resourced communities and move towards understanding the mechanisms contributing to differences in ADRD outcomes, we will then collect detailed and focused participant data using qualitative methods. Among a community-based sample of adults from under resourced communities, including those receiving hormone replacement therapy, this study component will explore psychosocial stressors expected to influence ADRD risk and cognitive impairment. Finally, we will develop and pilot test a data collection protocol that objectively assesses cognitive function, psychosocial stressors, and ADRD risk/protective factors among a cohort of middle-aged and older adults from under resourced communities. Research findings are expected to inform clinical practice and research by determining the extent of differences in ADRD outcomes among adults from under-resourced communities and across community subgroups, including people who may have used hormone replacement therapy, discerning psychosocial-related mechanisms associated with differences in ADRD outcomes, and establishing a protocol for a full-scale prospective cohort study of brain health and ADRD risk among adults from under-resourced communities.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $196,344 )
2026	2026	EMORY UNIVERSITY	201 DOWMAN DR NE	ATLANTA	GA	30322	DEKALB	USA	Aging Research	000	3	2/20/2026	NON-COMPETING CONTINUATION	$196,344
														Subtotal = $196,344

Issue Date FY: 2025 ( Subtotal = $196,344 )
2025	2025	EMORY UNIVERSITY	201 DOWMAN DR NE	ATLANTA	GA	30322	DEKALB	USA	Aging Research	000	2	12/5/2024	NON-COMPETING CONTINUATION	$196,344
														Subtotal = $196,344

Issue Date FY: 2024 ( Subtotal = $196,344 )
2024	2024	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Aging Research	000	1	11/10/2023	NEW	$196,344
2024	2024	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Aging Research	001	1	12/7/2023	NEW	$0
														Subtotal = $196,344

Grand Total All Awards = $589,032

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The Brain Health of Middle Aged and Older Adults Who May Use Hormone Therapy: An Examination of Alzheimer’s Disease and Related Dementias Risk and Psychosocial Stressors

Award Number: K23AG084851

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 12/01/2023

PERIOD OF PERFORMANCE END DATE: 11/30/2028

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