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Using Artificial Intelligence to Predict Cognitive Training Response in Amnestic Mild Cognitive Impairment

Award Number: K23AG080127
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 05/01/2023
PERIOD OF PERFORMANCE END DATE: 04/30/2028

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Using Artificial Intelligence to Predict Cognitive Training Response in Amnestic Mild Cognitive Impairment - Project Summary/Abstract: This K23 Clinical Trial project will provide Dr. Gullett, an Assistant Professor at the University of Florida, the direct mentored-training needed to address important questions related to intervention response in an amnestic mild cognitive impairment (aMCI) diagnosed population at risk for Alzheimer’s disease. As a neuropsychologist, Dr. Gullett has gained clinical experience in the assessment of neurodegenerative diseases including Alzheimer’s disease and its precursor, MCI, as well as research experience using structural neuroimaging to investigate various clinical disorders. The support provided by the K23 mechanism through the NIA will provide Dr. Gullett with the protected mentored-training needed to build on his current skills and become an expert in clinical neuroscience, machine learning, and behavioral interventions for mild cognitive impairment and Alzheimer’s disease. Career development and training plan: Dr. Gullett’s training plan consists of foundational formal coursework in 1) clinical trials, 2) MCI and Alzheimer’s disease effects, and 3) biostatistics and machine learning investigative techniques. These foundations will be directly applied through mentorship by experts in the fields of behavioral cognitive interventions, neuroimaging, and machine learning, as well as a proposed in-person workshop in functional neuroimaging analysis. This mentored-training plan will provide Dr. Gullett with the expertise to not only carry out the proposed project, but to become a unique and invaluable resource for future collaborative efforts applying neuroscience-based machine learning tools to investigate personalized interventions for Alzheimer’s disease. Research plan: The proposed project will provide the clinical trials training needed for Dr. Gullett to establish the effectiveness of a planned take-home, 12-week cognitive training program in patients with amnestic mild cognitive impairment (N=75; Aim 1). The expert mentorship team proposed has decades of experience in behavioral clinical trials interventions, which will provide the applicant with design and methodology guidance, as well as the recruitment infrastructure and resources needed to successfully carry out the proposed project. Further, this project will provide training in multi-modal neuroimaging-based machine learning to determine the baseline neural, cognitive, and functional factors that distinguish aMCI patients who respond to treatment from those who do not (Aim 2). This innovative approach will ultimately allow the applicant to investigate which of a myriad of features aMCI patients possess at a baseline assessment are the most salient predictors of their ability to improve from a well-validated cognitive training intervention. A project such as this will enable Dr. Gullett to develop a unique skillset to facilitate an R01-level academic career tasked with providing individual aMCI patients personalized interventions based on their own unique neurobiological and cognitive features.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $160,110 )
2026	2026	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Aging Research	000	4	3/26/2026	NON-COMPETING CONTINUATION	$160,110
														Subtotal = $160,110

Issue Date FY: 2025 ( Subtotal = $160,110 )
2025	2025	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Aging Research	000	3	5/20/2025	NON-COMPETING CONTINUATION	$160,110
														Subtotal = $160,110

Issue Date FY: 2024 ( Subtotal = $160,110 )
2024	2024	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Aging Research	000	2	4/24/2024	NON-COMPETING CONTINUATION	$160,110
														Subtotal = $160,110

Issue Date FY: 2023 ( Subtotal = $160,110 )
2023	2023	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Aging Research	000	1	4/19/2023	NEW	$160,110
														Subtotal = $160,110

Grand Total All Awards = $640,440

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Using Artificial Intelligence to Predict Cognitive Training Response in Amnestic Mild Cognitive Impairment

Award Number: K23AG080127

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 05/01/2023

PERIOD OF PERFORMANCE END DATE: 04/30/2028

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