Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Behavioral Interventions for the Treatment of Early Onset Alzheimer's Disease

Award Number: K23AG080071
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 05/01/2023
PERIOD OF PERFORMANCE END DATE: 04/30/2028

Group Awards By:

View Award Description

Behavioral Interventions for the Treatment of Early Onset Alzheimer's Disease - PROJECT SUMMARY/ABSTRACT This is a K23 application for Dr. Dustin Hammers, Associate Professor and neuropsychologist at Indiana University pursuing patient-oriented clinical research on lifestyle interventions in Early-Onset Alzheimer’s Disease (EOAD). This K23 will provide him the means to strategically transition from clinician to independent investigator through targeted coursework, didactics and workshops, and career products. The candidate’s supportive and successful institutional environment ensures that the formal career development plan will add to his existing expertise in neurodegenerative disease. His long-term career goal is to become an independent clinician-scientist with an externally funded research program that will enhance behavioral treatment options for patients with EOAD. Despite expansion of research on interventions for Alzheimer’s disease (AD), treatment for patients diagnosed at a younger stage of life has been overlooked, due to the rareness of the condition and challenges identifying disease modifying treatments in traditional-onset AD. These patients experience a unique set of complications related to personal and occupational functioning, including cognitive declines while raising families and performing at the height of their careers. Identification of successful treatments for this condition would lead to significant improvements for patients and their families across multiple aspects of life. The purpose of this 5-year research plan is to collect preliminary data through an NIH-defined Stage IB (NIH Stage Model) study to investigate the feasibility and pilot testing of a lifestyle intervention on short-term and long-term cognition, functioning, and mood in participants with EOAD. Specific Aim 1 will evaluate the feasibility of a lifestyle intervention combining cognitive training and Tai Chi in participants with EOAD, testing the hypotheses that the experimental and active control groups will have comparable attrition rates, and that the combined intervention will be well-tolerated. Specific Aim 2 will investigate if this intervention improves cognitive, functional, and mood outcomes in participants with EOAD compared to an active control condition. It is hypothesized that participants undergoing intervention will perform better on outcomes compared to control participants both post-treatment and at 6-months follow-up. Specific Aim 3 will examine if training or clinical variables moderate benefit from this combined lifestyle intervention. It will explore whether a greater treatment response will be seen in women with EOAD relative to men, and if better response will be related to increased hours of training and decreased disease severity. Outcome improvement from this lifestyle intervention would enhance the personal/occupational functioning of patients with EOAD, have implications for healthcare practice, policy, and clinical trials, and inform this intervention for all forms of AD. The candidate’s training in advanced neurodegeneration, AD trial operations, biostatistical approaches, and career development will complement his research plan, preparing him for future R01 submissions to more formally test this combined intervention and consider additional aspects of this intervention’s benefit in EOAD (transfer of benefit, etc.).


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $165,047 )
2026	2026	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	000	4	3/31/2026	NON-COMPETING CONTINUATION	$165,047
														Subtotal = $165,047

Issue Date FY: 2025 ( Subtotal = $162,961 )
2025	2025	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	000	3	5/20/2025	NON-COMPETING CONTINUATION	$162,961
														Subtotal = $162,961

Issue Date FY: 2024 ( Subtotal = $162,069 )
2024	2024	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	000	2	5/6/2024	NON-COMPETING CONTINUATION	$162,069
														Subtotal = $162,069

Issue Date FY: 2023 ( Subtotal = $168,349 )
2023	2023	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	000	1	4/25/2023	NEW	$168,349
														Subtotal = $168,349

Grand Total All Awards = $658,426

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Behavioral Interventions for the Treatment of Early Onset Alzheimer's Disease

Award Number: K23AG080071

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 05/01/2023

PERIOD OF PERFORMANCE END DATE: 04/30/2028

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer