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Odor memory and functional neuroimaging in cognitively impaired older adults and Alzheimer's disease

Award Number: K23AG076872
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 02/15/2023
PERIOD OF PERFORMANCE END DATE: 01/31/2029

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Odor memory and functional neuroimaging in cognitively impaired older adults and Alzheimer's disease - Project Summary This K23 application presents a training and research program that will support the applicant on a path towards becoming an NIH-funded independent investigator focused on understanding the neurobiology of the olfactory system in Alzheimer’s disease (AD). Training: The activities in this application build on the candidate’s prior clinical neuropsychology training and research experience and are set in a resource-rich environment that will foster his development of expertise in 1) principles of functional imaging in AD, 2) mechanisms and neural circuitry of the olfactory system, 3) biostatistics and psychometrics, and 4) responsible conduct of research. These training goals will be supported by a combination of didactics, formal advisory plans, and hands-on- practicum throughout the award period. Under the guidance of his primary mentor, Dr. Davangere Devanand, his co-mentor Dr. Terry Goldberg, scientific advisors (Drs. Gaurav Patel, Prasanna Karunanayaka, Mark Albers, Jonas Olofsson, and Scott Small), and peer mentor (Dr. Jonathan Overdevest), the candidate will acquire advanced skills in neuroimaging methodologies, olfactory evaluations, and AD biomarker mechanics that will be directly applied to this proposal. Research: The overarching goal of the research to be carried out in this application is to determine the neural mechanisms underlying odor memory deficits, and to define the relationship between odor memory and AD biomarkers using a new process-pure variant of an odor memory test. There is an urgent and unmet need to develop tools for enhancing early detection of AD. Olfaction and memory are systems in which impairments develop during initial stages of AD. Odor memory, which combines these two systems, has potential for improving upon the capabilities of existing tools which commonly measure either system in isolation. Currently, the precise neural substrates of odor memory remain undefined. By investigating the brain activation patterns involved in odor memory, there is promise for enhancing our ability to identify individuals at risk for decline. This proposal will be the first to evaluate odor detection and odor memory jointly within the same imaging paradigm. Aim 1 of the research project will examine fMRI task-related signal in the olfactory cortex and medial temporal lobe during an fMRI odor memory procedure. Patients with AD, patients with amnestic mild cognitive impairment, and cognitively intact older adults will undergo scanning. Aim 2 strives to establish the association of abnormal odor memory with apolipoprotein genotype and plasma tau biomarkers. In Aim 3, the clinical utility of odor memory for differentiating groups (patients with AD, patients with mild cognitive impairment, and cognitively intact older adults) will be compared against established odor identification and verbal memory measures.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $195,480 )
2026	2026	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Aging Research	001	3	2/9/2026	NON-COMPETING CONTINUATION	$195,480
2026	2024	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Aging Research	000	2	12/11/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $195,480

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Aging Research	000	2	3/19/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $195,470 )
2024	2024	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Aging Research	000	2	2/8/2024	NON-COMPETING CONTINUATION	$195,470
														Subtotal = $195,470

Issue Date FY: 2023 ( Subtotal = $195,434 )
2023	2023	RESEARCH FOUNDATION FOR MENTAL HYGIENE INC	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Aging Research	000	1	2/6/2023	NEW	$195,434
2023	2023	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Aging Research	001	1	8/18/2023	NEW	$0
														Subtotal = $195,434

Grand Total All Awards = $586,384

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Odor memory and functional neuroimaging in cognitively impaired older adults and Alzheimer's disease

Award Number: K23AG076872

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 02/15/2023

PERIOD OF PERFORMANCE END DATE: 01/31/2029

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