Thursday, October 2, 2025 10/2/2025

Using Routine Care Electronic Medical Record Data and Artificial Intelligence to Develop a Passive Digital Marker to Predict Postoperative Delirium

Award Number: K23AG071945
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 09/01/2022
PERIOD OF PERFORMANCE END DATE: 06/30/2027

Group Awards By:

View Award Description

Using Routine Care Electronic Medical Record Data and Artificial Intelligence to Develop a Passive Digital Marker to Predict Postoperative Delirium - PROJECT SUMMARY Postoperative delirium is among the most common complications following elective surgery. Delirium is associated with prolonged lengths of stay, functional decline, cognitive impairment, higher costs, and higher mortality. This proposal describes a career development plan that will transform Dr. Mohanty into a patient- oriented investigator focused on improving the perioperative brain health of every older American undergoing major surgery. Dr. Mohanty’s proposed project will involve merging the data of more than 35000 patients who underwent major surgery in a statewide health system with electronic health record (EHR) data from the Indiana Network for Patient Care (INPC), a Regional Health Information Exchange. Using this merged database, the candidate will develop and test a passive predictive model (“digital marker”) for postoperative delirium risk using routine care EHR data, including unstructured, free text notes, and a machine learning algorithm. This “digital marker” will then be tested in a pilot randomized clinical trial in preparation for a large efficacy trial which will evaluate the impact of this scalable “digital marker” on short and long-term cognitive outcomes. The proposed career development plan integrates: close mentoring from a multidisciplinary team of senior scientists; coursework and structured didactics in medical informatics, including advanced analytics, artificial intelligence, and clinical decision support; implementation science; experiential learning via the conduct of the proposed research project; and a supportive research environment. This environment includes an internationally recognized NIH-funded delirium study group, the distinguished Indiana University Center for Aging Research, the NIA-funded Indiana Alzheimer’s Disease Center, and the NIH-funded Indiana Clinical and Translational Sciences Institute (CTSI). This career development award will guarantee protected time that will be necessary to advance the candidate’s career in perioperative brain health. In addition, the award will provide critical support to collect data for a future R01 efficacy randomized controlled trial.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $141,820 )
2025	2025	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	000	4	9/8/2025	NON-COMPETING CONTINUATION	$141,820
														Subtotal = $141,820

Issue Date FY: 2024 ( Subtotal = $141,820 )
2024	2024	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	000	3	6/26/2024	NON-COMPETING CONTINUATION	$141,820
														Subtotal = $141,820

Issue Date FY: 2023 ( Subtotal = $141,056 )
2023	2023	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	000	2	7/31/2023	NON-COMPETING CONTINUATION	$141,056
														Subtotal = $141,056

Issue Date FY: 2022 ( Subtotal = $126,092 )
2022	2022	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	000	1	8/26/2022	NEW	$126,092
														Subtotal = $126,092

Grand Total All Awards = $550,788

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Using Routine Care Electronic Medical Record Data and Artificial Intelligence to Develop a Passive Digital Marker to Predict Postoperative Delirium

Award Number: K23AG071945

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 09/01/2022

PERIOD OF PERFORMANCE END DATE: 06/30/2027

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer