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Association of Perceived Stress and Cognition

Award Number: K23AG066931
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 01/15/2021
PERIOD OF PERFORMANCE END DATE: 12/31/2026

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Association of Perceived Stress and Cognition - Project/Summary Abstract African Americans are twice as likely to develop Alzheimer's disease (AD) as Whites, but few studies have focused on these cognitive disparities and related mechanisms. Perceived stress in minority groups such as African Americans, directly affects cognition and also plays a role in worsening of CVD risk factors and unhealthy behaviors such as smoking, improper diet, and physical inactivity. Further understanding the role of modifiable risk factors such as perceived stress in cognitive decline could have an important role in developing effective preventive strategies and addressing health disparities in aging populations. The overarching goal of this proposal is to examine the association of stress and cognition, role of CVD risk factors, and related health disparities. The research proposed in this Mentored Patient-Oriented Research Career Development Award includes data analyses involving two cohort studies and determining the feasibility of a pilot clinical trial. The plan describes three separate but interrelated projects designed to examine the association of perceived stress and cognition. Specific Aim-1: The study will prospectively examine the relationship between perceived stress and incident cognitive impairment among African Americans and Whites in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Cohort (n=30,239) and explore if CVD risk factors mediate this relationship. Specific Aim-2: The study will assess the relationship of perceived stress with specific cognitive domains among African Americans and Whites with Mild Cognitive Impairment in the Vascular Contributors to Prodromal Alzheimer's disease (VASCULAR) cohort study (n=341) at Emory. Specific Aim-3: The study will determine the feasibility of a novel web-based multidisciplinary stress reduction program and assess the program's effects on perceived stress, related biomarkers, and cognition among African Americans and Whites with Mild Cognitive Impairment (n=30). Candidate: The candidate (Dr. Kulshreshtha) is a board certified Family Physician in the Department of Family and Preventive Medicine at Emory University. His long-term career goal is to become an independent clinician researcher investigating the mechanisms of behavioral and lifestyle interventions to improve cognitive health and reduce health disparities. The integrated research and training program described in this proposal will build on the candidate's prior experience in cardiovascular epidemiology, health disparities, and primary care clinical work. It will incorporate new training in cognitive and stress measurements, and clinical trials, to develop expertise in the area of stress and cognition research for AD prevention. Overall this research will form the basis for larger studies investigating potential mechanisms and interventions for AD prevention and establish Dr. Kulshreshtha as a young investigator in patient-oriented clinical research.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	EMORY UNIVERSITY	201 DOWMAN DR NE	ATLANTA	GA	30322	DEKALB	USA	Aging Research	000	5	10/10/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $179,388 )
2025	2025	EMORY UNIVERSITY	201 DOWMAN DR NE	ATLANTA	GA	30322	DEKALB	USA	Aging Research	000	5	7/16/2025	NON-COMPETING CONTINUATION	$179,388
														Subtotal = $179,388

Issue Date FY: 2024 ( Subtotal = $179,388 )
2024	2024	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Aging Research	000	4	1/4/2024	NON-COMPETING CONTINUATION	$179,388
														Subtotal = $179,388

Issue Date FY: 2023 ( Subtotal = $179,388 )
2023	2023	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Aging Research	000	3	1/17/2023	NON-COMPETING CONTINUATION	$179,388
														Subtotal = $179,388

Issue Date FY: 2022 ( Subtotal = $179,388 )
2022	2022	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Aging Research	000	2	1/18/2022	NON-COMPETING CONTINUATION	$179,388
														Subtotal = $179,388

Issue Date FY: 2021 ( Subtotal = $179,388 )
2021	2021	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Aging Research	000	1	1/13/2021	NEW	$179,388
														Subtotal = $179,388

Grand Total All Awards = $896,940

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Association of Perceived Stress and Cognition

Award Number: K23AG066931

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 01/15/2021

PERIOD OF PERFORMANCE END DATE: 12/31/2026

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