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Transcriptional regulation of oncogenic cellular plasticity in the intestinal epithelium

Award Number: K22CA218462
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 09/14/2018
PERIOD OF PERFORMANCE END DATE: 02/28/2023

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Transcriptional regulation of oncogenic cellular plasticity in the intestinal epithelium - Project summary: The rewiring of transcriptional networks following oncogenic mutations is a poorly understood phenomenon. By integrating the two most commonly deregulated signaling pathways found in colon cancer, I have created mouse models to study the transcriptional programs that initiate and promote oncogenesis. The goal of the proposed project is to understand transcriptional regulation of tumor initiation and progression in vivo. The project is based on the hypothesis that the transcriptional program that regulate cellular plasticity drive and the maintain oncogenesis in vivo. Results from the proposed project will greatly impact the efforts to understand the mechanism of cellular plasticity that drive and maintain oncogenic plasticity. The proposal seeks to address two specific aims: 1) Determine the transcriptional program that regulates cellular plasticity in an inducible Smad4 knockout-β-catenin gain of function mutant mouse model, and 2) Determine the extent to which Smad4 functions as a gatekeeper of Wnt signaling, which drive tumor progression. The proposal will reveal the molecular function of Smad4 in suppressing cellular plasticity, thus enabling better understanding of oncogenesis and elucidate the transcriptional mechanism regulating colon tumor progression. The project is innovative in employing inducible mouse models to study cellular plasticity and tumor progression. It relies on the notion that “Stemness” whether it is inherent, or is acquired by the cell drive oncogenesis. Results from the project will impact our understandings on cellular plasticity that drive oncogenesis, and inform decisions on devising therapeutic strategies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$6,217 )
2024	2020	THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY	ONE CASTLE POINT ON HUDSON	HOBOKEN	NJ	07030	HUDSON	USA	Cancer Research Manpower	000	3	12/4/2023	NON-COMPETING CONTINUATION	-$6,217
														Subtotal = -$6,217

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2020	STEVENS INSTITUTE OF TECHNOLOGY (INC)	1 CASTLE POINT ON HUDSON	HOBOKEN	NJ	07030	HUDSON	USA	Cancer Research Manpower	000	3	8/24/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $162,000 )
2020	2020	STEVENS INSTITUTE OF TECHNOLOGY (INC)	1 CASTLE POINT ON HUDSON	HOBOKEN	NJ	07030	HUDSON	USA	Cancer Research Manpower	000	3	8/7/2020	NON-COMPETING CONTINUATION	$162,000
														Subtotal = $162,000

Issue Date FY: 2019 ( Subtotal = $162,000 )
2019	2019	STEVENS INSTITUTE OF TECHNOLOGY (INC)	1 CASTLE POINT ON HUDSON	HOBOKEN	NJ	07030	HUDSON	USA	Cancer Research Manpower	001	2	8/15/2019	NON-COMPETING CONTINUATION	$162,000
2019	2018	STEVENS INSTITUTE OF TECHNOLOGY (INC)	1 CASTLE POINT ON HUDSON	HOBOKEN	NJ	07030	HUDSON	USA	Cancer Research Manpower	000	1	2/12/2019	NEW	$0
														Subtotal = $162,000

Issue Date FY: 2018 ( Subtotal = $162,000 )
2018	2018	STEVENS INSTITUTE OF TECHNOLOGY (INC)	1 CASTLE POINT ON HUDSON	HOBOKEN	NJ	07030	HUDSON	USA	Cancer Research Manpower	000	1	9/14/2018	NEW	$162,000
														Subtotal = $162,000

Grand Total All Awards = $479,783

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Transcriptional regulation of oncogenic cellular plasticity in the intestinal epithelium

Award Number: K22CA218462

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 09/14/2018

PERIOD OF PERFORMANCE END DATE: 02/28/2023

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