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Cytokine regulation of recirculating and tissue-resident memory CD8+ T cells in homeostasis and inflammation

Award Number: K22AI177360
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 01/20/2026
PERIOD OF PERFORMANCE END DATE: 07/31/2027

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Cytokine regulation of recirculating and tissue-resident memory CD8+ T cells in homeostasis and inflammation - Project Summary/Abstract Memory CD8+ T cells are seeded throughout lymphoid and non-lymphoid tissues in the aftermath of acute infection. During this process, differentiation occurs into functionally distinct circulating and tissue-resident subsets which can then persist for years, decades, or even life. However, our understanding of this remarkable longevity is largely confined to studying circulating populations in homeostasis, neglecting the preponderance of tissue-resident memory T cells in non-lymphoid tissues and frequent perturbations caused by infection, inflammation, physiological and metabolic changes, etc. Through the proposed studies, the applicant will begin to address this knowledge gap by establishing how preexisting bystander memory CD8+ T cell subsets are maintained during homeostasis and infection via flexible use of cytokines, as addressed with infection models and cytokine therapy. Despite variable requirements for IL-15 between different memory CD8+ T cell populations, the applicant recently published that IL-15 sensitivity is a shared feature across memory subsets that operates within subset- and tissue-specific constraints. Dr. Jarjour proposes that as part of the memory CD8+ T cell program, memory cells gain the capacity to promiscuously utilize many different cytokines, thereby gaining resilience to stark alterations in availability during infection and other perturbations. This flexibility appears to operate within the confines of tissue- and subset- specific regulation, which the applicant will elucidate using his expertise in studying resident immune cells. Beyond revealing a key mechanism supporting durability of memory CD8+ T cells, these studies have implications for immunotherapies to expand memory CD8+ T cell populations, including during vaccination and cancer. The data generated through this proposal will form the basis for an R01 application and will position Dr. Jarjour for an independent career in basic immunology research, with long-term repercussions for human therapies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $40,833 )
2026	2026	VERSITI WISCONSIN, INC.	638 N 18TH ST	MILWAUKEE	WI	53233	MILWAUKEE	USA	Allergy and Infectious Diseases Research	000	1	1/17/2026	SUPPLEMENT FOR EXPANSION	$40,833
														Subtotal = $40,833

Issue Date FY: 2025 ( Subtotal = $162,000 )
2025	2025	VERSITI WISCONSIN, INC.	638 N 18TH ST	MILWAUKEE	WI	53233	MILWAUKEE	USA	Allergy and Infectious Diseases Research	000	1	8/12/2025	NEW	$162,000
														Subtotal = $162,000

Grand Total All Awards = $202,833

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Cytokine regulation of recirculating and tissue-resident memory CD8+ T cells in homeostasis and inflammation

Award Number: K22AI177360

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 01/20/2026

PERIOD OF PERFORMANCE END DATE: 07/31/2027

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