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Ca2+ signaling and ephaptic coupling in olfactory receptor neurons using lattice light-sheet microscopy

Award Number: K18DC018521
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 04/01/2020
PERIOD OF PERFORMANCE END DATE: 03/31/2023

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Ca2+ signaling and ephaptic coupling in olfactory receptor neurons using lattice light-sheet microscopy - Project Summary Olfactory receptor neurons (ORNs) are located in the olfactory epithelium in the nasal cavity and are the primary neurons that convert odorous information into nerve signals to be conveyed to the brain. As such, they drive a variety of behaviors including food localization, friend and foe recognition, and evaluation of reproductive status. Cilia that emanate from ORNs into the mucus that covers the epithelium are the site of olfactory transduction, and cilia from neighboring ORNs form an entangled mesh. Upon activation by odorants, a cAMP and Ca2+-based transduction cascade generates a ciliary transduction current that depolarizes the ORNs and leads to the generation of Ca2+-driven action potentials in the cell body. But little is known about the Ca2+ kinetics in cilia and the rest of the ORN, or how cilia from different ORNs might interact and influence each other within the environment of the mucus. The goal of this NIDCD Research Career Enhancement Award for Established Investigators proposal is to enhance the applicant’s current research program to learn and adopt cutting-edge lattice light sheet microscopy approaches to monitor Ca2+ responses in ORNs in the intact olfactory epithelium using genetically-encoded Ca2+ indicators. The long-term goal of the proposed mentored research experience is to understand how ORNs function in their polarized environment, how Ca2+ contributes to olfactory signaling and how the interaction of cilia in the mucosal environment contributes to coding and signaling of olfactory information.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2020	MONELL CHEMICAL SENSES CENTER	3500 MARKET ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	000	1	10/26/2023	NEW	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2020	MONELL CHEMICAL SENSES CENTER	3500 MARKET ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	001	1	6/22/2022	NEW	$0
2022	2020	MONELL CHEMICAL SENSES CENTER	3500 MARKET ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	000	1	12/10/2021	NEW	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $124,682 )
2020	2020	MONELL CHEMICAL SENSES CENTER	3500 MARKET ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	000	1	3/11/2020	NEW	$124,682
														Subtotal = $124,682

Grand Total All Awards = $124,682

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Ca2+ signaling and ephaptic coupling in olfactory receptor neurons using lattice light-sheet microscopy

Award Number: K18DC018521

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 04/01/2020

PERIOD OF PERFORMANCE END DATE: 03/31/2023

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