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PSYCHIATRIC DISORDERS FOLLOWING INTRAUTERINE STRESS

Award Number: K08MH085807
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 04/15/2009
PERIOD OF PERFORMANCE END DATE: 10/10/2012

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PSYCHIATRIC DISORDERS FOLLOWING INTRAUTERINE STRESS - DESCRIPTION (provided by applicant): I am obstetrician/gynecologist who recently completed a Schizophrenia Research Fellowship and an MPH in Epidemiology at the NewYork State Psychiatric Institute and Columbia University. I have now been recruited as a Research Assistant Professor to New York University's School of Medicine in the Department Psychiatry to contribute to the nucleus of the new Division of Molecular and Translational Medicine in Psychiatry. A major focus of this new Division will be to study the role of aberrant fetal neurodevelopment and adult neuropsychiatric outcomes. After discussion with my mentors, I have designed a rigorous training program consisting of formal coursework in epidemiology and statistics and the neurobiology of psychiatric disorders, laboratory training using animal models, management of large databases and training in ethical research. As a schizophrenia research fellow, I became increasingly interested in the effects of stress during pregnancy and neuropsychiatric outcomes in the offspring through my work with Dr. Dolores Malaspina, my primary mentor on this training grant. As an outgrowth of my work with Dr. Malaspina, I performed a study using animal models investigating stress during pregnancy and the behavioral outcomes of offspring in Dr. Michael Myers's (a mentor on this grant) laboratory at Columbia University. Through this work I became intensely interested in this area of study. As part of the research component of this grant, I will perform three epidemiologic studies. using existing databases, investigating the effects of acute stress in the population on women during pregnancy and the neuropsychiatric and neurocognitive outcomes of their offspring. In addition I will perform a series of experiments to examine neurobehavioral outcomes in offspring of pregnant rats administered glucocortoids during specific times of gestation. These complementary epidemiologic and animal model studies, along with the mentoring and training I will receive, will ensure that at the completion of this award I will be a successful independent scientist. PUBLIC HEALTH RELEVANCE: There have been many natural and manmade disasters in 2008. It is important to model the risk for psychopathology that is related to intrauterine exposure to violence and trauma. The work proposed here can help identify risk factors for psychiatric illnesses and can lay the foundation for the development of targeted interventions to reduce the risk of psychiatric disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2013 ( Subtotal = $0 )
2013	2012	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Mental Health Research Career/Scientist Development Awards	000	4	11/29/2012	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2012 ( Subtotal = $179,264 )
2012	2012	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Mental Health Research Career/Scientist Development Awards	000	4	1/18/2012	NON-COMPETING CONTINUATION	$179,264
														Subtotal = $179,264

Issue Date FY: 2011 ( Subtotal = $179,280 )
2011	2011	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Mental Health Research Career/Scientist Development Awards	000	3	4/1/2011	NON-COMPETING CONTINUATION	$179,280
														Subtotal = $179,280

Issue Date FY: 2010 ( Subtotal = $178,158 )
2010	2010	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Mental Health Research Career/Scientist Development Awards	000	2	3/29/2010	NON-COMPETING CONTINUATION	$178,158
2010	2009	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Mental Health Research Career/Scientist Development Awards	001	1	3/30/2010	NEW	$0
														Subtotal = $178,158

Issue Date FY: 2009 ( Subtotal = $179,280 )
2009	2009	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Mental Health Research Career/Scientist Development Awards	000	1	4/8/2009	NEW	$179,280
														Subtotal = $179,280

Grand Total All Awards = $715,982

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PSYCHIATRIC DISORDERS FOLLOWING INTRAUTERINE STRESS

Award Number: K08MH085807

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 04/15/2009

PERIOD OF PERFORMANCE END DATE: 10/10/2012

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