Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Genetic and Transcriptomic Resilience in Chronic Obstructive Pulmonary Disease

Award Number: K08HL168205
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 01/15/2024
PERIOD OF PERFORMANCE END DATE: 12/31/2028

Group Awards By:

View Award Description

Genetic and Transcriptomic Resilience in Chronic Obstructive Pulmonary Disease - PROJECT SUMMARY I am an academic clinician scientist with a focus on the genetics of respiratory diseases. My overarching career goal is to make an important contribution to the public health burden of chronic respiratory diseases. I aim to become an independent investigator with the skill set to utilize integrative ‘omic techniques for the improved biological understanding and clinical management of chronic obstructive pulmonary disease (COPD). The proposed research combines my prior experience in genetics and transcriptomics with training in genetic association, transcriptomic analyses, and machine learning, in order to better understand the variability in COPD genetic risk. The hypothesis of this proposal is that there are genetic variants and transcriptomic factors that are associated with resilience to COPD. This will be tested by leveraging existing data from multiple well-phenotyped studies from the NHLBI TransOmics for Precision Medicine (TOPMed) program. Specific Aims: (1) Identify genetic variation associated with resilience to COPD against a background of elevated genetic risk; (2) Define clinical, imaging, and blood gene-expression features of COPD resilience; and (3) Predict lung-tissue gene-expression profiles of COPD risk and resilience from blood gene-expression data. The cutting-edge research plan utilizes innovative methodologies to characterize genetic and transcriptomic resilience to COPD. It is accompanied by a training plan that will provide me with the skills to complete the research aims and the experience to transition to an independent research career. I plan to submit an R01 expanding upon the characterization of genetic and transcriptomic resilience in COPD by combining multi-omic risk- and resilience-scoring and lung-tissue gene-expression imputation to improve understanding of the biological mechanisms that contribute to observed clinical heterogeneity in COPD. In particular, I have four training goals that build upon my existing background in respiratory genetics. (1) Strengthen my knowledge of biostatistics, statistical genomics, and bioinformatic methods; (2) Expand my skills in transcriptomic methodologies; (3) Gain experience and expertise in the development and implementation of machine-learning algorithms; and (4) Further develop my mentoring skills and understanding of study design. I am supported by a mentoring team with complementary skillsets and successful mentoring careers, which, together with my experience, training, and substantial preliminary data, will guarantee the success of this proposal. The findings may pave the way for the development of precision risk-prediction approaches, while implementing a novel methodology to address one of the most important challenges in the field today: identification of genetic and transcriptomic resilience to COPD.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $203,738 )
2026	2026	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	750 E ADAMS ST	SYRACUSE	NY	13210	ONONDAGA	USA	Lung Diseases Research	000	3	2/9/2026	NON-COMPETING CONTINUATION	$203,738
														Subtotal = $203,738

Issue Date FY: 2025 ( Subtotal = $200,364 )
2025	2025	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	750 E ADAMS ST	SYRACUSE	NY	13210	ONONDAGA	USA	Lung Diseases Research	000	2	2/19/2025	NON-COMPETING CONTINUATION	$200,364
														Subtotal = $200,364

Issue Date FY: 2024 ( Subtotal = $203,764 )
2024	2024	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	750 E ADAMS ST	SYRACUSE	NY	13210	ONONDAGA	USA	Lung Diseases Research	000	1	1/10/2024	NEW	$203,764
														Subtotal = $203,764

Grand Total All Awards = $607,866

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Genetic and Transcriptomic Resilience in Chronic Obstructive Pulmonary Disease

Award Number: K08HL168205

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 01/15/2024

PERIOD OF PERFORMANCE END DATE: 12/31/2028

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer