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Informing national guidelines on adolescent and young adult physical activity and sedentary behavior to prevent cardiovascular disease

Award Number: K08HL159350
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

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Informing national guidelines on adolescent and young adult physical activity and sedentary behavior to prevent cardiovascular disease - PROJECT SUMMARY / ABSTRACT Cardiovascular disease (CVD) is the leading cause of death in the United States and physical activity is a potent way to decrease this risk. Serious gaps remain in our understanding of the optimal duration of physical activity and sedentary behavior during adolescence and young adulthood if risk for concurrent and future CVD is to be averted, and were specifically identified as priority research areas in the 2018 Department of Health and Human Services (HHS) Physical Activity Guidelines for Americans. Adolescence and young adulthood are critical transition periods that set physical activity patterns for the rest of adulthood and may represent a critical window for early intervention. The overall objective of this K08 is to develop evidence to bridge the HHS-articulated gaps by describing independent effects of sedentary behavior in adolescence and thresholds of physical activity in young adulthood on the prevention of later-life CVD to inform future HHS guidelines. The central hypothesis is that highly sedentary adolescents and young adults will require higher physical activity levels to reduce CVD risk in later adulthood. This project will analyze longitudinal cohort data from the Adolescent Brain Cognitive Development (ABCD) Study, the National Longitudinal Study of Adolescent to Adult Health (Add Health), and the Coronary Artery Risk Development in Young Adults (CARDIA) Study. The Specific Aims will: (1) determine independent associations of contemporary forms of sedentary behavior (screen time) in adolescents with CVD risk factor incidence; (2) evaluate associations of attaining HHS-recommended adolescent (60 mins/day, 7 days/week) versus adult (30 mins/day, 5 days/week) physical activity levels during specific age ranges in young adulthood with incidence of CVD risk factors; and (3) estimate population-level lifetime effects of adolescent and young adult sedentary behaviors, physical activity dose, and their interactions on later-life CVD mortality. The candidate’s long-term career objective is to become an independent physician-epidemiologist generating actionable evidence to optimize adolescent and young adult behaviors to prevent CVD later in life. The proposed career development plan will provide training and mentorship in: (1) physical activity, sedentary behavior, and CVD epidemiology and measurement; (2) longitudinal analyses and modeling methods; (3) guideline development and implementation; and (4) career development and plan for independence. Training will be achieved through coursework, seminars, tutorials, conferences, hands-on experience, and active mentoring. The mentoring team includes nationally recognized experts in cardiovascular epidemiology, adolescent and young adult medicine, physical activity/sedentary behavior, biostatistics, guideline development, and implementation science. Completion of this K08 will inform specific guidance for adolescents and young adults in the next edition of the Physical Activity Guidelines for Americans. The K08 will support a future R01 grant using implementation science and modeling approaches to promote attainment of national physical activity guidelines to prevent CVD, aligned with NHLBI’s strategic vision of reducing heart disease through data and implementation science.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $173,910 )
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Cardiovascular Diseases Research	000	4	7/23/2024	NON-COMPETING CONTINUATION	$173,910
														Subtotal = $173,910

Issue Date FY: 2023 ( Subtotal = $173,910 )
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Cardiovascular Diseases Research	000	3	8/17/2023	NON-COMPETING CONTINUATION	$173,910
														Subtotal = $173,910

Issue Date FY: 2022 ( Subtotal = $173,790 )
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Cardiovascular Diseases Research	001	2	7/27/2022	NON-COMPETING CONTINUATION	$173,790
2022	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Cardiovascular Diseases Research	000	1	5/11/2022	NEW	$0
														Subtotal = $173,790

Issue Date FY: 2021 ( Subtotal = $173,790 )
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Cardiovascular Diseases Research	000	1	8/18/2021	NEW	$173,790
														Subtotal = $173,790

Grand Total All Awards = $695,400

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Informing national guidelines on adolescent and young adult physical activity and sedentary behavior to prevent cardiovascular disease

Award Number: K08HL159350

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

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