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Evaluating Comparative Effectiveness of Glucose-lowering Therapy in People with HIV and Type 2 Diabetes

Award Number: K08DK146757
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 04/01/2026
PERIOD OF PERFORMANCE END DATE: 03/31/2031

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Evaluating Comparative Effectiveness of Glucose-lowering Therapy in People with HIV and Type 2 Diabetes - PROJECT SUMMARY In the era of modern antiretroviral therapy (ART), cardiometabolic diseases have become a leading cause of morbidity and mortality among people with HIV (PWH). Type 2 diabetes, a major contributor to cardiovascular and kidney disease, now affects approximately one in five PWH. PWH face unique metabolic challenges due to HIV infection and ART, including chronic inflammation and disrupted glucose and lipid metabolism. Despite these distinct metabolic derangements, population-specific evidence guiding the pharmacologic management of diabetes in PWH remains limited. This project seeks to generate real-world evidence addressing critical knowledge gaps on the comparative effectiveness of commonly used glucose-lowering agents—metformin, glucagon-like peptide-1 receptor agonists, dipeptidyl peptidase-4 inhibitors, sodium-glucose cotransporter-2 inhibitors, and sulfonylureas. The candidate is an internal medicine physician with a background in pharmacoepidemiology at Johns Hopkins University. During the award period, he will be mentored by a multidisciplinary team whose expertise spans diabetes and cardiometabolic comorbidities in PWH, machine learning, and causal inference methods. His long-term career goal is to become an independent clinician-investigator applying innovative machine learning and epidemiologic methods to improve clinical care for PWH with diabetes and other chronic conditions. The overarching objective of this project is to generate robust evidence to inform the pharmacologic management of type 2 diabetes among PWH. The proposed study will focus on three aims: (1) characterize the utilization of glucose-lowering therapies; (2) evaluate the comparative effectiveness of glucose-lowering therapies on glycemic control; and (3) estimate the effect of different glucose-lowering therapies on cardiovascular and renal outcomes and mortality among PWH with diabetes. This work will leverage the North American AIDS Cohort Collaboration on Research and Design (NA- ACCORD), a large, representative, multi-site cohort of over 190,000 people with HIV in the United States and Canada. Comparing glucose-lowering therapies on key clinical outcomes will generate population-specific evidence to inform clinical care for the growing population with HIV and diabetes. In parallel, the project will support the candidate’s development of the expertise needed to become an independent investigator capable of applying advanced quantitative methods to generate robust clinical evidence and improve the treatment of diabetes and other chronic conditions among PWH.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $169,927 )
2026	2026	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	3/24/2026	NEW	$169,927
														Subtotal = $169,927

Grand Total All Awards = $169,927

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Evaluating Comparative Effectiveness of Glucose-lowering Therapy in People with HIV and Type 2 Diabetes

Award Number: K08DK146757

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 04/01/2026

PERIOD OF PERFORMANCE END DATE: 03/31/2031

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