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MOLECULAR ANALYSIS OF SCARLESS FETAL WOUND HEALING

Award Number: K08DE014780
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 07/28/2003
PERIOD OF PERFORMANCE END DATE: 05/31/2008

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MOLECULAR ANALYSIS OF SCARLESS FETAL WOUND HEALING - DESCRIPTION (provided by applicant): Adult mammalian tissues respond to injury by healing with scar formation. Scar tissue assists in sealing a wound, but can also lead to significant morbidity. Scar can restrict tendon and muscle movement, obstruct visceral lumens, and impede peripheral nerve regeneration. In the head and neck especially scarring can have severe consequences, causing hearing loss, loss of smell and taste, loss of voice and articulation, airway obstruction, as well as the obvious stigma of gross visible deformity. In contrast to adults, mammalian fetuses are known to heal without scar in a process akin to regeneration. This remarkable ability is known to be intrinsic to fetal tissues, independent of the uterine environment, and is lost in the third trimester of gestation. An understanding of the biological basis for scarless healing might well lead to new strategies to limit the morbidity of scar. We hypothesize that scarless fetal wound healing drives from a subset of differentially expressed genes in fetuses versus adults. The aims of this project are to establish microarrays that encompass the full relevant gene set comprising the expressomes of healing fetal and adult wounds, to identify differentially regulated genes, to better characterize selected differentially regulated gene products, and to confirm differential expression at the protein level through a proteomics approach. We will evaluate promising candidate genes thus identified for their biological significance in a number of model systems, including transgenic and knockout animals, and through the use of somatic gene transfer. We will also investigate possible mechanisms controlling the fetal wound-specific downregulation of the eta chaperonin subunit. With these complementary approaches we hope to thereby arrive at a broad understanding of the gene patterns controlling both fetal and adult wound healing, and identify gene products/pathways critical to both.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2007 ( Subtotal = $124,927 )
2007	2007	ALLEGHENY SINGER RESEARCH CORP	2 ALLEGHENY CTR, 11TH FLOOR	PITTSBURGH	PA	15212	ALLEGHENY	USA	Oral Diseases and Disorders Research	000	5	5/30/2007	NON-COMPETING CONTINUATION	$124,927
														Subtotal = $124,927

Issue Date FY: 2006 ( Subtotal = $124,927 )
2006	2006	ALLEGHENY SINGER RESEARCH CORP	2 ALLEGHENY CTR, 11TH FLOOR	PITTSBURGH	PA	15212	ALLEGHENY	USA	Oral Diseases and Disorders Research	000	4	5/26/2006	NON-COMPETING CONTINUATION	$124,927
														Subtotal = $124,927

Issue Date FY: 2005 ( Subtotal = $124,927 )
2005	2005	ALLEGHENY SINGER RESEARCH CORP	503 MARTINDALE STREET	PITTSBURGH	PA	15212	ALLEGHENY	USA	Oral Diseases and Disorders Research	000	3	5/31/2005	NON-COMPETING CONTINUATION	$124,927
														Subtotal = $124,927

Issue Date FY: 2004 ( Subtotal = $124,927 )
2004	2004	ALLEGHENY SINGER RESEARCH CORP	503 MARTINDALE STREET	PITTSBURGH	PA	15212	ALLEGHENY	USA	Oral Diseases and Disorders Research	000	2	5/4/2004	NON-COMPETING CONTINUATION	$124,927
														Subtotal = $124,927

Issue Date FY: 2003 ( Subtotal = $124,927 )
2003	2003	ALLEGHENY SINGER RESEARCH CORP	503 MARTINDALE STREET	PITTSBURGH	PA	15212	ALLEGHENY	USA	Oral Diseases and Disorders Research	000	1	7/28/2003	NEW	$124,927
														Subtotal = $124,927

Grand Total All Awards = $624,635

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MOLECULAR ANALYSIS OF SCARLESS FETAL WOUND HEALING

Award Number: K08DE014780

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 07/28/2003

PERIOD OF PERFORMANCE END DATE: 05/31/2008

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