Tuesday, March 10, 2026 3/10/2026

MR1-dependent presentation of Mycobacterium tuberculosis: a unique role for calcium signaling

Award Number: K08AI153359
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 06/01/2020
PERIOD OF PERFORMANCE END DATE: 11/30/2025

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MR1-dependent presentation of Mycobacterium tuberculosis: a unique role for calcium signaling - Project Summary The fundamental role of the immune system is to detect self from non-self. The detection and elimination of microbial infection is critical for human survival. One challenge to the immune system is infection from an intracellular microbe because the microbe masks its presence in a host cell. One strategy of the immune system to detect microbes is the sampling of different kinds of antigens, such as peptides, lipids and glycolipids, by antigen presenting molecules. A fundamentally unique arm of the immune system is MR1, which is an antigen presenting molecule that is intracellular, ubiquitously expressed across tissues, and detects small molecules derived from microbial metabolism. These features suggest that MR1 is poised to detect intracellular microbes. MR1 presents antigens to MR1-restricted T cells. These T cells are highly prevalent in the lungs and have the ability to kill infected cells. Because MR1 presents small molecule antigens and adopts an intracellular distribution, the mechanisms governing MR1 sampling of the intracellular environment are distinct from other antigen presenting molecules. Our hypothesis is that endosomal recycling and endosomal calcium signaling are key for MR1-dependent antigen presentation, and that these features distinguish MR1 from MHC- Ia antigen presentation. We use Mycobacterium tuberculosis (Mtb) as a model for intracellular infection and have identified calcium-sensitive trafficking proteins and calcium channels important for MR1 antigen presentation. In Aim 1, we will define the role of the endosomal trafficking protein Syntaxin 16 in MR1- dependent antigen presentation. In Aim 2, we will define the role of calcium sensitive Synaptotagmins in MR1- dependent antigen presentation. In Aim 3, we will identify the important calcium channels involved in this process and examined the role of Two-pore channels. This research plan is part of a detailed training and career development plan for the applicant. In addition to hands-on basic science research with an emphasis on techniques such as measurement of intracellular calcium and live-cell fluorescence microscopy, the applicant will complete coursework in scientific writing and biostatistics to expand scientific knowledge and will attend scientific conferences to develop collaborations. Acquisition of all of these skills will lead to expertise in defining intracellular signaling cascades in antigen presenting cells, with the goal of obtaining an R01 by the end of the K08 award. The primary mentor has a long track record of training scientists and a Mentoring Committee will track the applicant's progress and contribute to the applicant's development as a scientist. Finally, the sponsoring institution, Oregon Health & Science University, has all the facilities and support necessary to support the proposal.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2024	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Allergy and Infectious Diseases Research	000	5	12/10/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $184,788 )
2024	2024	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Allergy and Infectious Diseases Research	000	5	5/21/2024	NON-COMPETING CONTINUATION	$184,788
														Subtotal = $184,788

Issue Date FY: 2023 ( Subtotal = $183,168 )
2023	2023	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Allergy and Infectious Diseases Research	000	4	5/3/2023	NON-COMPETING CONTINUATION	$183,168
														Subtotal = $183,168

Issue Date FY: 2022 ( Subtotal = $185,544 )
2022	2022	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Allergy and Infectious Diseases Research	000	3	5/27/2022	NON-COMPETING CONTINUATION	$185,544
														Subtotal = $185,544

Issue Date FY: 2021 ( Subtotal = $185,544 )
2021	2021	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Allergy and Infectious Diseases Research	000	2	6/1/2021	NON-COMPETING CONTINUATION	$185,544
														Subtotal = $185,544

Issue Date FY: 2020 ( Subtotal = $185,760 )
2020	2020	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Allergy and Infectious Diseases Research	000	1	5/29/2020	NEW	$185,760
														Subtotal = $185,760

Grand Total All Awards = $924,804

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MR1-dependent presentation of Mycobacterium tuberculosis: a unique role for calcium signaling

Award Number: K08AI153359

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 06/01/2020

PERIOD OF PERFORMANCE END DATE: 11/30/2025

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