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Memory T follicular helper cell kinetics and localization during recall immune responses to tetanus vaccination

Award Number: K08AI141761
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 08/12/2019
PERIOD OF PERFORMANCE END DATE: 07/31/2024

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Memory T follicular helper cell kinetics and localization during recall immune responses to tetanus vaccination - Project Summary/Abstract T follicular helper cells (Tfh) are a type of immune system cell that provide critical support in the generation of antibodies during vaccination. Understanding the mechanism by which these cells support highly efficacious and durable vaccine responses could assist in the development of novel vaccines targeting diseases such as malaria. Most of our knowledge on the characteristics and function of Tfh has come from basic immunology research done in mice. To study Tfh responses in mice, the convention has been to sample specialized immune tissues such as lymph nodes and spleen. In humans, these tissues are not readily accessible for study, so human immunologists study blood Tfh responses. Unfortunately, blood Tfh are thought to travel to lymphoid tissue when their relevant antigen enters the body. Thus, study of Tfh responses in blood is unlikely to reveal the helper T cell functions during vaccination that lead to the antibodies that provide protective immunity. The proposed project aims to characterize the Tfh response in both blood and lymphoid tissue in mouse and human hosts in response to vaccination. The goal of this work will be to determine whether measuring blood Tfh can be reliably used to study lymph node Tfh responses in human studies. During this study we will develop and optimize highly innovative techniques including vaccine-specific Tfh cell tracking, combined with lymph node mapping and serial lymph node sampling. These techniques will be used to track vaccine specific Tfh responses at their primary site of action. This project will serve as the foundation for future Tfh studies of vaccines, providing key technologies for studying Tfh and knowledge about Tfh localization during a vaccine response. These tools and knowledge will then be used to study Tfh responses in malaria vaccines, which have low efficacy in field-based studies. The goal of these future studies will be to inform novel vaccine design and administration protocols in pursuit of a highly efficacious malaria vaccine.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Allergy and Infectious Diseases Research	000	5	2/18/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $194,370 )
2023	2023	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Allergy and Infectious Diseases Research	000	5	7/17/2023	NON-COMPETING CONTINUATION	$194,370
														Subtotal = $194,370

Issue Date FY: 2022 ( Subtotal = $195,647 )
2022	2022	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Allergy and Infectious Diseases Research	000	4	7/25/2022	NON-COMPETING CONTINUATION	$195,647
														Subtotal = $195,647

Issue Date FY: 2021 ( Subtotal = $196,887 )
2021	2021	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Allergy and Infectious Diseases Research	000	3	7/22/2021	NON-COMPETING CONTINUATION	$196,887
														Subtotal = $196,887

Issue Date FY: 2020 ( Subtotal = $198,091 )
2020	2020	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Allergy and Infectious Diseases Research	000	2	6/17/2020	NON-COMPETING CONTINUATION	$198,091
														Subtotal = $198,091

Issue Date FY: 2019 ( Subtotal = $199,260 )
2019	2019	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	701 PARK AVE	MINNEAPOLIS	MN	55415	HENNEPIN	USA	Allergy and Infectious Diseases Research	000	1	8/9/2019	NEW	$199,260
														Subtotal = $199,260

Grand Total All Awards = $984,255

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Memory T follicular helper cell kinetics and localization during recall immune responses to tetanus vaccination

Award Number: K08AI141761

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 08/12/2019

PERIOD OF PERFORMANCE END DATE: 07/31/2024

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