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The role of Mucosal-associated invariant T (MAIT) cells during the innate immune response to Mycobacterium tuberculosis

Award Number: K08AI132739
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 06/06/2018
PERIOD OF PERFORMANCE END DATE: 05/31/2023

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The role of Mucosal-associated invariant T (MAIT) cells during the innate immune response to Mycobacterium tuberculosis - Project Summary/Abstract Charles Kyriakos Vorkas, MD is a Fellow in Infectious Diseases at Weill Cornell Medicine (WCM) and a member of the Glickman Laboratory, Memorial Sloan Kettering Cancer Center (MSKCC) whose research interests focus upon Innate immunity during Mycobacterium tuberculosis (Mtb) infection. He plans to pursue a career as a physician-scientist in the field of Tuberculosis (TB) immunology. This proposal describes a five-year training program that will provide the candidate with the knowledge and technical skills to achieve this goal. In addition to intensive laboratory-based experimental training, the proposal includes regular meetings with an advisory committee of experts, active involvement in academic conferences, and formal coursework. At the end of the period of support, the candidate will be prepared to embark on a career as an independent investigator. Little is known about the host factors that influence clearance of Mtb infection, control of latency or progression to active disease. The candidates' work will focus on the role of mucosal- associated invariant T (MAIT) cells in innate immunity to Mtb using an ex vivo MAIT cell activation assay in Haitian donors. MAIT cells are MR1-restricted lymphocytes that recognize bacterially- derived Vitamin B metabolites and data suggest that they act early at mucosal surfaces during Mtb infection. The candidate will investigate immune correlates of resistance to Mtb infection through analysis of three Haitian cohorts: (1) active TB patients (2) healthy household contacts of TB patients and (3) healthy community volunteers without reported exposure. The candidate will also screen synthetic MR1 ligand analogs for effects on MR1 regulation and MAIT activation and test if they can restrict bacterial growth through priming MAIT cells in a monocyte-derived macrophage co-culture model of Mtb infection. This study proposes to identify immune correlates of innate resistance to Mtb infection, which may have direct translational applications for TB immunotherapy or vaccine design.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$8 )
2024	2022	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	W5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	6	2/27/2024	NON-COMPETING CONTINUATION	-$8
														Subtotal = -$8

Issue Date FY: 2022 ( Subtotal = $184,264 )
2022	2022	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Allergy and Infectious Diseases Research	002	6	5/16/2022	NON-COMPETING CONTINUATION	$184,264
2022	2021	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	1300 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Allergy and Infectious Diseases Research	000	4	12/17/2021	NON-COMPETING CONTINUATION	-$149,338
2022	2021	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	W5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Allergy and Infectious Diseases Research	005	5	5/24/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$40,483
2022	2021	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	1300 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Allergy and Infectious Diseases Research	004	4	5/24/2022	NON-COMPETING CONTINUATION	-$34,926
2022	2021	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Allergy and Infectious Diseases Research	001	5	12/17/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$149,338
2022	2020	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	1300 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Allergy and Infectious Diseases Research	003	3	5/24/2022	NON-COMPETING CONTINUATION	-$5,557
														Subtotal = $184,264

Issue Date FY: 2021 ( Subtotal = $184,264 )
2021	2021	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	1300 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Allergy and Infectious Diseases Research	000	4	5/26/2021	NON-COMPETING CONTINUATION	$184,264
														Subtotal = $184,264

Issue Date FY: 2020 ( Subtotal = $184,264 )
2020	2020	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	407 E 61ST ST RM 106 1ST FL	NEW YORK	NY	10065	NEW YORK	USA	Allergy and Infectious Diseases Research	000	3	5/13/2020	NON-COMPETING CONTINUATION	$184,264
														Subtotal = $184,264

Issue Date FY: 2019 ( Subtotal = $184,264 )
2019	2019	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	407 E 61ST ST RM 106 1ST FL	NEW YORK	NY	10065	NEW YORK	USA	Allergy and Infectious Diseases Research	001	2	5/2/2019	NON-COMPETING CONTINUATION	$184,264
2019	2018	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	407 E 61ST ST RM 106 1ST FL	NEW YORK	NY	10065	NEW YORK	USA	Allergy and Infectious Diseases Research	000	1	4/29/2019	NEW	$0
														Subtotal = $184,264

Issue Date FY: 2018 ( Subtotal = $184,264 )
2018	2018	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	407 E 61ST ST RM 106 1ST FL	NEW YORK	NY	10065	NEW YORK	USA	Allergy and Infectious Diseases Research	000	1	6/6/2018	NEW	$184,264
														Subtotal = $184,264

Grand Total All Awards = $921,312

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The role of Mucosal-associated invariant T (MAIT) cells during the innate immune response to Mycobacterium tuberculosis

Award Number: K08AI132739

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 06/06/2018

PERIOD OF PERFORMANCE END DATE: 05/31/2023

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