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RISK FOR FUTURE OUTBREAKS OF HENIPAVIRUSES IN SOUTH ASIA

Award Number: K08AI067549
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 09/22/2009
PERIOD OF PERFORMANCE END DATE: 08/31/2011

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RISK FOR FUTURE OUTBREAKS OF HENIPAVIRUSES IN SOUTH ASIA - DESCRIPTION (provided by applicant): Many emerging diseases are caused by zoonotic pathogens which spillover from wildlife reservoirs to humans following changes in demography, behavior or environment. Veterinarians can provide important input into research on emerging zoonoses, but specific training programs for these are lacking. The proposed training program will provide multidisciplinary training in molecular and serological diagnostic techniques and mathematical modeling of disease dynamics of a lethal zoonosis. Nipah virus (NiV) is a recently discovered, lethal, Class C potential bioterror pathogen with a case fatality rate of 40 - 79% in humans and for which no vaccines, nor clinically-proven therapies exist. Fruit bats (Pteropus spp.), have been identified as the natural reservoir for NiV and related viruses in Asia and Australia. Since 2001, NiV has caused five recognized outbreaks in Bangladesh and one in India. In contrast to Malaysia, where the virus first emerged, no intermediate animal host has been identified in Bangladesh, and there is evidence of direct bat-to-human transmission and person-to-person transmission. The specific aims of this proposal are to: 1) Examine the distribution of NiV in flying foxes (Pteropus giganteus) in Bangladesh and bat migration among colonies by catching and testing bats for NiV using serological and molecular techniques, and satellite telemetry; 2) Test the hypothesis that seasonal NiV outbreaks in Bangladesh correspond to seasonal spikes in viral prevalence in fruit bat reservoirs during pregnancy and synchronous birthing, by conducting a longitudinal study within a bat colony in an area adjacent to a human NiV outbreak; and 3) Develop a parameterized predictive model for Nipah virus emergence in Bangladesh using data from this research to inform the model. I will co-analyse human epidemiological data with bat transmission data to identify specific temporal, spatial and contact risks for NiV spillover. Results from this study can be used to inform public health policy for the prevention of Nipah virus outbreaks. Ultimately, I hope to create a model for identifying "hotspots" of high risk for NiV outbreaks in Bangladesh which can then be extrapolated to other countries where fruit bats occur such as India. This training program will provide a unique opportunity to develop my skills as a veterinary epidemiologist so that I can design and lead future research on the causes of zoonotic disease emergence.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2010 ( Subtotal = $130,950 )
2010	2010	WILDLIFE TRUST INC	1200 LINCOLN AVENUE	PROSPECT PARK	PA	19076	DELAWARE	USA	Allergy and Infectious Diseases Research	000	4	9/14/2010	NON-COMPETING CONTINUATION	$130,950
2010	2009	WILDLIFE TRUST INC	1200 LINCOLN AVENUE	PROSPECT PARK	PA	19076	DELAWARE	USA	Trans-NIH Recovery Act Research Support	001	3	9/30/2010	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $130,950

Issue Date FY: 2009 ( Subtotal = $180,944 )
2009	2009	WILDLIFE TRUST INC	1200 LINCOLN AVENUE	PROSPECT PARK	PA	19076	DELAWARE	USA	Trans-NIH Recovery Act Research Support	001	3	9/15/2009	SUPPLEMENT FOR EXPANSION	$49,994
2009	2009	WILDLIFE TRUST INC	1200 LINCOLN AVENUE	PROSPECT PARK	PA	19076	DELAWARE	USA	Allergy and Infectious Diseases Research	000	3	9/3/2009	NON-COMPETING CONTINUATION	$130,950
														Subtotal = $180,944

Issue Date FY: 2008 ( Subtotal = $130,950 )
2008	2008	WILDLIFE TRUST INC	1200 LINCOLN AVENUE	PROSPECT PARK	PA	19076	DELAWARE	USA	Allergy and Infectious Diseases Research	000	2	8/15/2008	NON-COMPETING CONTINUATION	$130,950
														Subtotal = $130,950

Issue Date FY: 2007 ( Subtotal = $130,950 )
2007	2007	WILDLIFE TRUST INC	1200 LINCOLN AVENUE	PROSPECT PARK	PA	19076	DELAWARE	USA	Allergy and Infectious Diseases Research	000	1	9/7/2007	NEW	$130,950
														Subtotal = $130,950

Grand Total All Awards = $573,794

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RISK FOR FUTURE OUTBREAKS OF HENIPAVIRUSES IN SOUTH ASIA

Award Number: K08AI067549

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 09/22/2009

PERIOD OF PERFORMANCE END DATE: 08/31/2011

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