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BRAIN STIMULATION MODELS OF DRUG ABUSE

Award Number: K05DA000099
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 12/10/1993
PERIOD OF PERFORMANCE END DATE: 12/31/2008

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BRAIN STIMULATION MODELS OF DRUG ABUSE - DESCRIPTION (provided by applicant): The major long-term objective of this scientist award is to conduct research comparing young and old rat's response to opiates and cocaine. Preliminary data has suggested major differences in reward mechanisms between young and old rats. As the population grows older the number of elderly individuals with drug dependence may sharply increase; the issue, however, of drug abuse in aging has, for the most part, been ignored. There is considerable evidence that with aging there are alterations in the brain systems implicated in the mediation of the hedonic effects of abused substances. A major aspect of the proposed research will examine the functional consequences of these alterations using a number of animal models of the rewarding effects of abused substances. Specifically the abuse substances studied will be morphine, heroin and cocaine as well as specific substances that alter the relevant neurotransmitter systems that are believed involved in the rewarding effects of these abused substances. The experimental animal will be the rat and the specific models used will be drug self-administration, conditioned place preference, and brain stimulation reward. In addition the specific dopamine (DA) agonist GBR 12009 will be investigated. DA within the nucleus accumbens will be measured using in vivo micro-dialysis in aged and young animals following the administration of morphine, GBR 12909 and BSR, alone and in combination. Another area or research will to experimentally investigate basal changes in the brain that are precipitated by the presentation of environmental cues that previously had been associated with alcohol during drinking bouts in rats this model will make use of the quantitative 2-deoxy-glucose ((2-DG) Auto radiographic method of determining local cerebral metabolic rate of glucose metabolism. In addition to the research experiments it is proposed to write a historical review of the behavioral methods that have been used in the study of abused substances.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2008 ( Subtotal = $120,820 )
2008	2008	BOSTON UNIVERSITY	25 BUICK STREET	BOSTON	MA	02215	SUFFOLK	USA	Drug Abuse Scientist Development Awards, Research Scientist Development Awards, and Research Scientist Awards	000	25	1/31/2008	NON-COMPETING CONTINUATION	$120,820
														Subtotal = $120,820

Issue Date FY: 2007 ( Subtotal = $120,820 )
2007	2007	BOSTON UNIVERSITY	25 BUICK STREET	BOSTON	MA	02215	SUFFOLK	USA	Drug Abuse Scientist Development Awards, Research Scientist Development Awards, and Research Scientist Awards	000	24	1/12/2007	NON-COMPETING CONTINUATION	$120,820
														Subtotal = $120,820

Issue Date FY: 2006 ( Subtotal = $120,820 )
2006	2006	BOSTON UNIVERSITY	25 BUICK STREET	BOSTON	MA	02215	SUFFOLK	USA	Drug Abuse Scientist Development Awards, Research Scientist Development Awards, and Research Scientist Awards	000	23	12/22/2005	NON-COMPETING CONTINUATION	$120,820
														Subtotal = $120,820

Issue Date FY: 2005 ( Subtotal = $120,820 )
2005	2005	BOSTON UNIVERSITY	25 BUICK STREET	BOSTON	MA	02215	SUFFOLK	USA	Drug Abuse Scientist Development Awards, Research Scientist Development Awards, and Research Scientist Awards	000	22	5/25/2005	NON-COMPETING CONTINUATION	$120,820
														Subtotal = $120,820

Issue Date FY: 2004 ( Subtotal = $120,820 )
2004	2004	BOSTON UNIVERSITY	25 BUICK STREET	BOSTON	MA	02215	SUFFOLK	USA	Drug Abuse Scientist Development Awards, Research Scientist Development Awards, and Research Scientist Awards	000	21	1/12/2004	COMPETING CONTINUATION	$120,820
														Subtotal = $120,820

Issue Date FY: 2003 ( Subtotal = $117,515 )
2003	2003	BOSTON UNIVERSITY	25 BUICK STREET	BOSTON	MA	02215	SUFFOLK	USA	Drug Abuse Scientist Development Awards, Research Scientist Development Awards, and Research Scientist Awards	000	20		NON-COMPETING CONTINUATION	$117,515
														Subtotal = $117,515

Issue Date FY: 2002 ( Subtotal = $117,515 )
2002	2002	BOSTON UNIVERSITY	25 BUICK STREET	BOSTON	MA	02215	SUFFOLK	USA	Drug Abuse Scientist Development Awards, Research Scientist Development Awards, and Research Scientist Awards	000	19	12/6/2001	NON-COMPETING CONTINUATION	$117,515
														Subtotal = $117,515

Issue Date FY: 2001 ( Subtotal = $117,515 )
2001	2001	BOSTON UNIVERSITY	25 BUICK STREET	BOSTON	MA	02215	SUFFOLK	USA	Drug Abuse Scientist Development Awards, Research Scientist Development Awards, and Research Scientist Awards	000	18	12/8/2000	NON-COMPETING CONTINUATION	$117,515
														Subtotal = $117,515

Issue Date FY: 2000 ( Subtotal = $117,515 )
2000	2000	Trustees Of Boston University	25 BUICK STREET	BOSTON	MA	02215	SUFFOLK	USA	Drug Abuse Scientist Development Awards, Research Scientist Development Awards, and Research Scientist Awards	000	17	12/1/1999	NON-COMPETING CONTINUATION	$117,515
														Subtotal = $117,515

Issue Date FY: 1999 ( Subtotal = $100,278 )
1999	1999	Trustees Of Boston University	25 BUICK STREET	BOSTON	MA	02215	SUFFOLK	USA	Drug Abuse Scientist Development Awards, Research Scientist Development Awards, and Research Scientist Awards	000	16	12/30/1998	COMPETING CONTINUATION	$100,278
														Subtotal = $100,278

Issue Date FY: 1998 ( Subtotal = $100,197 )
1998	1998	Trustees Of Boston University	25 BUICK STREET	BOSTON	MA	02215	SUFFOLK	USA	Drug Abuse Scientist Development Awards, Research Scientist Development Awards, and Research Scientist Awards	000	15	11/24/1997	NON-COMPETING CONTINUATION	$100,197
														Subtotal = $100,197

Grand Total All Awards = $1,274,635

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BRAIN STIMULATION MODELS OF DRUG ABUSE

Award Number: K05DA000099

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 12/10/1993

PERIOD OF PERFORMANCE END DATE: 12/31/2008

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