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BRAIN MECHANISMS OF ANTICIPATORY PROCESSING IN ANXIETY DISORDERS

Award Number: K02MH082130
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 09/01/2008
PERIOD OF PERFORMANCE END DATE: 07/31/2013

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BRAIN MECHANISMS OF ANTICIPATORY PROCESSING IN ANXIETY DISORDERS - DESCRIPTION (provided by applicant): Anxiety disorders are a debilitating form of mental illness that affect many people and carry a high societal and economic burden. A central feature of these disorders is the excessive anticipation of potential adverse outcomes. Considerable work in the candidate's and others' labs has identified multiple brain areas recruited during the anticipation of aversive events. The primary research objectives of this application are to probe these areas for abnormalities during anticipation in anxiety disorder patients and to examine the impact of uncertainty and uncontrollability, which figure prominently in anxiety. The planned research will also assess functional associations and white matter connections among the brain networks identified. In service of that, training in functional and structural connectivity methods is the major focus of the career development plan. These rapidly developing areas examining connectivity are an obvious next step for the candidate's research program and career development and will be crucial in his efforts to continue contributing to our developing knowledge base about brain function in anxiety. The environment is ideal for the pursuit of these research and career development objectives, with outstanding facilities, collaborators, and resources as well as a high degree of support from both the Department of Psychiatry and the Waisman Center. The proposed research will examine anticipatory function in generalized anxiety disorder and social anxiety disorder using a picture paradigm designed and developed in the candidate's laboratory over the past 7 years. The high levels of comorbidity with depression for these two anxiety disorders will be systematically investigated by including patients with major depressive disorder. The discovery of neural abnormalities in anticipatory processes should add to the body of work already being used in developing new clinical tools for directly targeting specific brain regions in anxiety and depression, such as transcranial magnetic stimulation, epidural electrocortical stimulation, and deep brain stimulation. Psychotherapy clients may benefit from greater focus of intervention strategies on anticipatory processes relevant to their symptoms. Research findings from the proposed project might have implications for determining which individuals would be likely to benefit from a particular treatment, building on recent findings by the candidate and his colleagues that greater anticipatory activity in the anterior cingulate predicts better response to an 8-week medication trial.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2013 ( Subtotal = $9,723 )
2013	2012	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 N PARK ST	MADISON	WI	53715	DANE	USA	Mental Health Research Career/Scientist Development Awards	000	5	4/22/2013	NON-COMPETING CONTINUATION	$2,013
2013	2011	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 N PARK ST	MADISON	WI	53715	DANE	USA	Mental Health Research Career/Scientist Development Awards	003	4	4/22/2013	NON-COMPETING CONTINUATION	$2,014
2013	2010	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 N PARK ST	MADISON	WI	53715	DANE	USA	Mental Health Research Career/Scientist Development Awards	002	3	4/22/2013	NON-COMPETING CONTINUATION	$1,955
2013	2009	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 N PARK ST	MADISON	WI	53715	DANE	USA	Mental Health Research Career/Scientist Development Awards	001	2	4/22/2013	NON-COMPETING CONTINUATION	$1,898
2013	2008	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 N PARK ST	MADISON	WI	53715	DANE	USA	Mental Health Research Career/Scientist Development Awards	004	1	4/22/2013	NEW	$1,843
														Subtotal = $9,723

Issue Date FY: 2012 ( Subtotal = $95,798 )
2012	2012	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 N PARK ST	MADISON	WI	53715	DANE	USA	Mental Health Research Career/Scientist Development Awards	000	5	7/16/2012	NON-COMPETING CONTINUATION	$95,798
														Subtotal = $95,798

Issue Date FY: 2011 ( Subtotal = $95,797 )
2011	2011	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 N PARK ST	MADISON	WI	53715	DANE	USA	Mental Health Research Career/Scientist Development Awards	000	4	7/14/2011	NON-COMPETING CONTINUATION	$95,797
														Subtotal = $95,797

Issue Date FY: 2010 ( Subtotal = $93,007 )
2010	2010	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 N PARK ST	MADISON	WI	53715	DANE	USA	Mental Health Research Career/Scientist Development Awards	000	3	7/8/2010	NON-COMPETING CONTINUATION	$93,007
														Subtotal = $93,007

Issue Date FY: 2009 ( Subtotal = $90,298 )
2009	2009	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 N PARK ST	MADISON	WI	53715	DANE	USA	Mental Health Research Career/Scientist Development Awards	000	2	7/15/2009	NON-COMPETING CONTINUATION	$90,298
														Subtotal = $90,298

Issue Date FY: 2008 ( Subtotal = $87,668 )
2008	2008	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 NORTH PARK STREET	MADISON	WI	53715	DANE	USA	Mental Health Research Career/Scientist Development Awards	000	1	8/25/2008	NEW	$87,668
														Subtotal = $87,668

Grand Total All Awards = $472,291

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BRAIN MECHANISMS OF ANTICIPATORY PROCESSING IN ANXIETY DISORDERS

Award Number: K02MH082130

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 09/01/2008

PERIOD OF PERFORMANCE END DATE: 07/31/2013

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