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Optimizing Brief Alcohol Interventions for Young Adults via Computational Methods

Award Number: K02AA028630
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 06/01/2021
PERIOD OF PERFORMANCE END DATE: 05/31/2026

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Optimizing Brief Alcohol Interventions for Young Adults via Computational Methods - Project Summary The goal of this Independent Scientist Award (K02) is to seek “protected time” for a period of intensive research focus to enhance the Candidate’s career development and to conduct research on the comparative effectiveness of competing brief alcohol interventions and their mechanisms. The proposed research strategy represents an ongoing, NIAAA-supported independent research program (R01 AA019511: Estimating Comparative Effectiveness of Alcohol Interventions for Young Adults, received 3rd percentile score). This K02 extends the R01 by (1) including an additional 25 data sets of individual participant data from brief alcohol interventions conducted between 2013 and 2020, and (2) embracing machine learning algorithms and other state-of-the-art statistical methods to help identify mechanisms of behavior change and to integrate and synthesize them across heterogeneous studies. The proposed protected time will be critical to update and enrich my research program in this current, rapidly changing clinical research environment. With accumulating high-quality clinical data and real-world data in the context of emerging data science capabilities, there exist opportunities as well as challenges. I am well suited to tackle emerging challenges for unprecedented opportunities, given my work in statistical data integration and broad experience in alcohol research. I want to create a large database where one can simultaneously examine secular/cohort effects, intervention effects, and effect heterogeneity at the most granular data level by developing and using new tools. My career goal is to become “one of the major hubs,” connecting disparate networks of researchers into a large connected network, promoting fluid interactions. The synergy from the large, interdisciplinary network would be helpful toward creating a “value” proposition of Big Data – the sum of the knowledge and insights from the collaboration by investigators is greater than isolated pursuits by each. Toward this goal, career development activities will be to (1) train in computational machine learning algorithms and real-world large-dimensional data analysis to facilitate collaboration with addiction researchers and statisticians; (2) enhance my understanding of technology-assisted adaptive interventions and passively collected outcomes data; (3) update my knowledge in basic health sciences related to addiction; and (4) submit at least two publications and two grants per year using newly acquired knowledge and skills proposed under K02. I have identified six highly active, nationally acclaimed experts in their respective fields. I will have individual and group research meetings with all six collaborators (three new collaborators for this K02) to develop innovative projects. In addition, I will attend workshops and conferences for training, carry out online training, and have guided reading and discussion with collaborators. I will visit collaborators for in-depth discussions and problem-solving. Improving big data capabilities for biomedical and clinical research has been one of the major strategic plans of the NIH, and I am motivated and prepared to help meet that critical mission.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $128,579 )
2025	2025	THE UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER AT FORT WORTH	3500 CAMP BOWIE BLVD	FORT WORTH	TX	76107	TARRANT	USA	Alcohol Research Programs	000	5	7/17/2025	NON-COMPETING CONTINUATION	$128,579
														Subtotal = $128,579

Issue Date FY: 2024 ( Subtotal = $132,683 )
2024	2024	THE UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER AT FORT WORTH	3500 CAMP BOWIE BLVD	FORT WORTH	TX	76107	TARRANT	USA	Alcohol Research Programs	000	4	5/30/2024	NON-COMPETING CONTINUATION	$132,683
														Subtotal = $132,683

Issue Date FY: 2023 ( Subtotal = $134,303 )
2023	2023	UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER AT FORT WORTH	3500 CAMP BOWIE BLVD	FORT WORTH	TX	76107	TARRANT	USA	Alcohol Research Programs	000	3	6/1/2023	NON-COMPETING CONTINUATION	$134,303
														Subtotal = $134,303

Issue Date FY: 2022 ( Subtotal = $138,083 )
2022	2022	UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER AT FORT WORTH	3500 CAMP BOWIE BLVD	FORT WORTH	TX	76107	TARRANT	USA	Alcohol Research Programs	000	2	5/31/2022	NON-COMPETING CONTINUATION	$138,083
														Subtotal = $138,083

Issue Date FY: 2021 ( Subtotal = $134,843 )
2021	2021	UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER AT FORT WORTH	3500 CAMP BOWIE BLVD	FORT WORTH	TX	76107	TARRANT	USA	Alcohol Research Programs	000	1	5/10/2021	NEW	$134,843
														Subtotal = $134,843

Grand Total All Awards = $668,491

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Optimizing Brief Alcohol Interventions for Young Adults via Computational Methods

Award Number: K02AA028630

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 06/01/2021

PERIOD OF PERFORMANCE END DATE: 05/31/2026

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