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Lymphatic Regulation of Neutrophil Phenotypes in Wound Healing: A Microphysiological Approach with Microbiome-Based Therapeutic Insights

Award Number: K01OD040624
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 07/15/2026
PERIOD OF PERFORMANCE END DATE: 06/30/2030

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Lymphatic Regulation of Neutrophil Phenotypes in Wound Healing: A Microphysiological Approach with Microbiome-Based Therapeutic Insights - Project Summary/Abstract Skin, the body’s largest organ, undergoes a tightly regulated healing process following injury, consisting of inflammation, regeneration and maturation. This process can be disrupted by microbial overgrowth, often resulting in infection and impaired healing. The growing prevalence of antibiotic-resistant infections poses a serious threat to public health and if not effectively controlled, these infections can escalate to sepsis and death. A hallmark of infection-related complications is unregulated inflammation, which can further damage tissues and hinder repair. Neutrophils are among the first immune responders to tissue injury and, under normal conditions, play a key role in controlling infection and promoting repair. Some pathogens, namely Staphylococcus aureus, have evolved strategies to evade neutrophil killing, enhancing their ability to spread. The lymphatic system is thought to regulate neutrophil clearance and coordinate immune responses, offering a potential mechanism for controlling excessive inflammation and infection. In parallel, the skin microbiome is increasingly recognized for its role in modulating immune responses and presents a promising therapeutic avenue to restore balance and promote healing. To study these interactions, we developed a physiologically relevant microphysiological system (MPS) using LumeNEXT technology, which mimics the wound microenvironment with primary human cells, reducing reliance on animal models. Using this system, we observed that the presence of lymphatic endothelium enhances neutrophil migration in response to bacterial challenge, suggesting coordinated immune-lymphatic- microbial dynamics. This research aims to deepen our understanding of early wound healing mechanisms using this advanced in vitro model and explore microbiome-based strategies to control inflammation and prevent infection - ultimately reducing dependence on antibiotics.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $130,383 )
2026	2026	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Research Infrastructure Programs	000	1	7/7/2026	NEW	$130,383
														Subtotal = $130,383

Grand Total All Awards = $130,383

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Lymphatic Regulation of Neutrophil Phenotypes in Wound Healing: A Microphysiological Approach with Microbiome-Based Therapeutic Insights

Award Number: K01OD040624

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 07/15/2026

PERIOD OF PERFORMANCE END DATE: 06/30/2030

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