Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Multidimensional brain connectome features of depression and anxiety

Award Number: K01MH131855
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 01/16/2023
PERIOD OF PERFORMANCE END DATE: 12/31/2027

Group Awards By:

View Award Description

Multidimensional brain connectome features of depression and anxiety - PROJECT SUMMARY Disrupted communication between brain regions responsible for emotion regulation (limbic and higher cognitive cortical regions) may critically underlie the emotional dysregulation that characterizes mood and anxiety disorders. However, the most instructive metric of such communication has yet to be agreed upon. In addition, due to technical barriers, there are currently no fine-grained measurements of limbic subregion connectivity in humans. A network- based approach can be used to explore limbic and cortical subregion connectivity (i.e. connectome), shedding light on the discrete or shared neural mechanisms underlying core symptoms in mood and anxiety disorders. In the proposed study we will (1) characterize small limbic subregions and whole-brain connectomes in healthy controls and individuals with major depressive and generalized anxiety disorder, by optimizing and employing a novel 7-Tesla MRI protocol with improved spatial resolution with whole brain coverage; (2) discern network based biomarkers of depression and anxiety by developing and characterizing a multi-modal integrative brain network consisting of structural, functional and dynamic topographies using a new computational multilayer approach; and (3) transdiagnostically examine how connectome organization manifests across the three study groups. By portraying specific limbic subregion involvement in the brain connectome, this would advance our understanding of how connectome alternations manifest in psychiatric disorders. Furthermore, this work combines high-resolution measures of brain activity and synchronization (functional MRI), with maps of the brain’s white matter architecture and anatomical connections (diffusion MRI). Their combined study will facilitate identification of aberrant network features and their contributions to core symptoms in depression and anxiety. Lastly, the transdiagnostic approach will uncover shared and unique network mechanisms of depression and anxiety that could potentially provide improved diagnostics and treatment selection. This Career Development Award will allow for the critical complimentary training goals centering on: (1) gaining practical clinical experience towards identifying clinical needs and conducting translational research; (2) development of technical advanced MRI sequence development skills; (3) refine computational skills in advanced network science methods. The proposed research and training afforded by this award will allow me to launch an independent research program developing neuroimaging methods to study brain network perturbations in mood and anxiety disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2027 ( Subtotal = $0 )
2027	2026	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Mental Health Research Grants	000	4	10/8/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2026 ( Subtotal = $176,750 )
2026	2026	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Mental Health Research Grants	000	4	1/22/2026	NON-COMPETING CONTINUATION	$176,750
														Subtotal = $176,750

Issue Date FY: 2025 ( Subtotal = $176,961 )
2025	2025	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Mental Health Research Grants	000	3	12/5/2024	NON-COMPETING CONTINUATION	$176,961
														Subtotal = $176,961

Issue Date FY: 2024 ( Subtotal = $177,771 )
2024	2024	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Mental Health Research Grants	000	2	12/13/2023	NON-COMPETING CONTINUATION	$177,771
														Subtotal = $177,771

Issue Date FY: 2023 ( Subtotal = $178,644 )
2023	2023	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Mental Health Research Grants	000	1	1/12/2023	NEW	$178,644
														Subtotal = $178,644

Grand Total All Awards = $710,126

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Multidimensional brain connectome features of depression and anxiety

Award Number: K01MH131855

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 01/16/2023

PERIOD OF PERFORMANCE END DATE: 12/31/2027

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer