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Developing and testing a telehealth intervention to increase HIV pre-exposure prophylaxis uptake and adherence

Award Number: K01MH129165
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 09/20/2022
PERIOD OF PERFORMANCE END DATE: 08/31/2027

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Developing and testing a telehealth intervention to increase HIV pre-exposure prophylaxis uptake and adherence - Revised Project Summary: While the HIV epidemic continues to persist, there are effective HIV prevention biomedical interventions. With high adherence, daily oral pre-exposure prophylaxis (PrEP) reduces risk for HIV acquisition. Increasing PrEP uptake and adherence could significantly reduce HIV incidence, but to date there are limited PrEP interventions, especially for populations most impacted by the virus. The scientific premise of this K01 application is that a telehealth delivery model for PrEP could circumvent barriers to PrEP access. There is a strong proof of concept for the proposed approach given that telehealth interventions to enhance PrEP access have been shown to be acceptable and have increased PrEP uptake and adherence. While telehealth interventions have increased utilization of other health services, few studies has investigated the feasibility, acceptability, and efficacy of delivering PrEP health services through a telehealth approach. Overview of project. My long-term goal is to become an independent researcher with expertise in developing and testing telehealth interventions to improve HIV prevention and care outcomes. In Year 1, I will conduct qualitative interviews with HIV-negative participants (n=20), peer educators (n=20), and healthcare providers (n=20) to identify the content, format, and foreseeable challenges to implementing a telemedicine intervention to increase PrEP awareness, uptake, and adherence. In Year 2,-3 I will conduct qualitative interviews (n=30) to iteratively design a telemedicine intervention to increase PrEP uptake and adherence. In Years 4-5, I will conduct a pilot randomized controlled trial (RCT) to test the feasibility, acceptability, and preliminary efficacy of the telemedicine intervention to optimize PrEP adherence over 6 months with 90 PrEP-naïve, HIV-negative participants. My successful completion of the proposed research and training aims will position me to submit a R01 in the final year of this grant to conduct a multisite, RCT to test the intervention’s efficacy.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $195,054 )
2025	2025	THE RAND CORPORATION	1776 MAIN ST	SANTA MONICA	CA	90401	LOS ANGELES	USA	Mental Health Research Grants	001	4	9/2/2025	NON-COMPETING CONTINUATION	$152,214
2025	2025	THE RAND CORPORATION	1776 MAIN ST	SANTA MONICA	CA	90401	LOS ANGELES	USA	Mental Health Research Grants	002	4	9/5/2025	SUPPLEMENT FOR EXPANSION	$42,840
2025	2024	THE RAND CORPORATION	1776 MAIN ST	SANTA MONICA	CA	90401	LOS ANGELES	USA	Mental Health Research Grants	000	3	12/6/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $195,054

Issue Date FY: 2024 ( Subtotal = $195,054 )
2024	2024	THE RAND CORPORATION	1776 MAIN ST	SANTA MONICA	CA	90401	LOS ANGELES	USA	Mental Health Research Grants	000	3	9/1/2024	NON-COMPETING CONTINUATION	$195,054
														Subtotal = $195,054

Issue Date FY: 2023 ( Subtotal = $196,314 )
2023	2023	THE RAND CORPORATION	1776 MAIN ST	SANTA MONICA	CA	90401	LOS ANGELES	USA	Mental Health Research Grants	000	2	8/30/2023	NON-COMPETING CONTINUATION	$196,314
														Subtotal = $196,314

Issue Date FY: 2022 ( Subtotal = $198,465 )
2022	2022	RAND CORPORATION, THE	1776 MAIN ST	SANTA MONICA	CA	90401	LOS ANGELES	USA	Mental Health Research Grants	000	1	9/20/2022	NEW	$198,465
														Subtotal = $198,465

Grand Total All Awards = $784,887

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Developing and testing a telehealth intervention to increase HIV pre-exposure prophylaxis uptake and adherence

Award Number: K01MH129165

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 09/20/2022

PERIOD OF PERFORMANCE END DATE: 08/31/2027

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