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Identification of Distinct Multimodal Biotypes of PTSD Using Data Driven Approach: A Multisite Big Data Study

Award Number: K01MH122774
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 12/10/2020
PERIOD OF PERFORMANCE END DATE: 01/12/2025

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Identification of Distinct Multimodal Biotypes of PTSD Using Data Driven Approach: A Multisite Big Data Study - Posttraumatic stress disorder (PTSD) is a highly prevalent and debilitating disorder. Despite efforts to characterize the pathophysiology of PTSD and its heterogenity, no objective biomarker have been established to aid in diagnosis, and prediction of treatment response. This K01 presents a program for research and training that will support the applicant on a path towards becoming an independent investigator, focused on utilizing a data-driven computational approach and machine learning techniques to identify multimodal neural biomarkers of PTSD (supervised) and multimodal biotypes of PTSD (unsupervised) and explore whether such biotypes could be used to predict response to prolonged exposure (PE), the first line treatment for PTSD. The training plan builds on the candidate’s prior training and experience and capitalizes on a mentorship team and a research environment to foster development of the candidate’s expertise in 1) the neural and behavioral basis of PTSD and anxiety disorders; 2) multimodal data fusion analysis and latent dimension interpretation with data-driven computational approaches and data reproducibility; and 3) patient-oriented translational research in anxiety disorders. This research project will apply both supervised and unsupervised machine learning techniques on multimodal MRI data from the largest existing PTSD dataset (N~3000 from the ENIGMA-PTSD working group). Biotypes identified from this large dataset will then be extended to clinical treatment data. The results of the proposed research will be vital to aid in finding neural biomarkers of PTSD and better predict different treatment outcomes through different biotype targets and will lead to a future R01 grant examining brain-symptoms association across anxiety and trauma-related disorders, and to use the newly identified PTSD biotypes to inform different treatment outcomes in a following R61/33. Together, the research and training experiences and expertise developed through this K01 award will support the applicant’s transition to research independence and ensure the applicant becomes a leading authority in the application of data-driven computational approaches in psychiatry research, and provide the basis for future NIMH grants to explore biotypes from multimodal brain imaging using data-driven computational approaches across anxiety-related disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$32,768 )
2025	2024	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	001	4	5/19/2025	NON-COMPETING CONTINUATION	-$32,768
2025	2024	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	000	4	1/13/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = -$32,768

Issue Date FY: 2024 ( Subtotal = $176,267 )
2024	2024	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	000	4	4/2/2024	NON-COMPETING CONTINUATION	$176,267
														Subtotal = $176,267

Issue Date FY: 2023 ( Subtotal = $175,879 )
2023	2023	RESEARCH FOUNDATION FOR MENTAL HYGIENE INC	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	000	3	11/22/2022	NON-COMPETING CONTINUATION	$175,879
2023	2023	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	001	3	9/28/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $175,879

Issue Date FY: 2022 ( Subtotal = $175,911 )
2022	2022	RESEARCH FOUNDATION FOR MENTAL HYGIENE INC	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	000	2	11/5/2021	NON-COMPETING CONTINUATION	$175,911
														Subtotal = $175,911

Issue Date FY: 2021 ( Subtotal = $176,916 )
2021	2021	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	000	1	12/10/2020	NEW	$176,916
														Subtotal = $176,916

Grand Total All Awards = $672,205

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Identification of Distinct Multimodal Biotypes of PTSD Using Data Driven Approach: A Multisite Big Data Study

Award Number: K01MH122774

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 12/10/2020

PERIOD OF PERFORMANCE END DATE: 01/12/2025

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