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Sex-Specific Brain and Behavioral Predictors of Cognitive Aging in Middle-Aged Adults with Autism Spectrum Disorder

Award Number: K01MH116098
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 06/01/2018
PERIOD OF PERFORMANCE END DATE: 05/31/2024

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Sex-Specific Brain and Behavioral Predictors of Cognitive Aging in Middle-Aged Adults with Autism Spectrum Disorder - Project Summary/Abstract Research Project Long-Term Objective: The long-term objective of this research is to describe the cognitive challenges associated with aging in adults with ASD to inform interventions and care plans. Aim 1: Identify the combination of sex-specific functional and structural brain measures in adults with ASD that (a) best describe age-related cognitive changes compared to matched-NT controls and (b) predict age-related cognitive decline. Methods: We will use multi-modal partial least squared analysis to elucidate information linkage between complementary neuroimaging data sets. Research Design: We will analyze both cross-sectional data of young-adult (n=100) vs. middle-aged (n=120) ASD and NT groups, and longitudinal data of middle-aged adults in two year increments (n=120 participants; 360 data sets). Men and women will be similarly represented in groups (M:F ratio, 1.0 : 0.7). Aim 2: Identify the combination of behavioral measures in adults with ASD that best predict age-related cognitive decline. Methods: We will use multi-task learning to determine the linkage between complementary behavioral data sets. Research Design: We will analyze cross-sectional and longitudinal data from Aim 1 ASD participants. Health Relatedness: These aims will have a substantial positive impact on health care quality and costs in the ASD community by vertically advancing our understanding of the unique cognitive and brain aging process, and laying the groundwork for delivering effective, precision medicine care to the growing and vulnerable population of older adults with ASD. Candidate Career Goals: Dr. Braden's long-term goal is to become a leading researcher in the neurobiology of aging in ASD through a multi-disciplinary program from basic science to translational treatment. Her short-term goals are to: 1) comprehensively describe age-related cognitive and brain changes in adults with ASD, and 2) identify targets for behavioral and neurobiological interventions and care plans tailored to specific cognitive needs of older adults with ASD. Career Development Plan: Building on her strong foundation in multi-disciplinary cognitive aging neuroscience, Dr. Braden will have intensive training in: 1) advanced neuroimaging analytics, 2) ASD phenotyping and interventions, and 3) professional and programmatic development for leading a funded multi-disciplinary research effort. Environment: Each training aim has an expert mentor across three local institutions with abundant academic overlap. Dr. Braden's home institution, Arizona State University, is one of the fastest growing research enterprise among all U.S. universities, and specializes in the neuroscience of cognitive and brain aging. She will also receive training at the Banner Alzheimer's Institute, an internationally recognized research and patient care program, and the Southwest Autism Research and Resource Center, an ASD community-based center of excellence.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2021	ARIZONA STATE UNIVERSITY	660 S MILL AVENUE STE 204	TEMPE	AZ	85281	MARICOPA	USA	Mental Health Research Grants	000	4	8/21/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Mental Health Research Grants	000	4	5/4/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $53,991 )
2022	2022	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Mental Health Research Grants	000	4	7/22/2022	SUPPLEMENT FOR EXPANSION	$53,991
														Subtotal = $53,991

Issue Date FY: 2021 ( Subtotal = $177,359 )
2021	2021	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Mental Health Research Grants	000	4	6/18/2021	NON-COMPETING CONTINUATION	$177,359
														Subtotal = $177,359

Issue Date FY: 2020 ( Subtotal = $177,541 )
2020	2020	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Mental Health Research Grants	001	3	6/24/2020	NON-COMPETING CONTINUATION	$0
2020	2020	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Mental Health Research Grants	000	3	6/17/2020	NON-COMPETING CONTINUATION	$177,541
														Subtotal = $177,541

Issue Date FY: 2019 ( Subtotal = $174,842 )
2019	2019	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Mental Health Research Grants	000	2	7/3/2019	NON-COMPETING CONTINUATION	$174,842
														Subtotal = $174,842

Issue Date FY: 2018 ( Subtotal = $176,252 )
2018	2018	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Mental Health Research Grants	000	1	5/17/2018	NEW	$176,252
														Subtotal = $176,252

Grand Total All Awards = $759,985

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Sex-Specific Brain and Behavioral Predictors of Cognitive Aging in Middle-Aged Adults with Autism Spectrum Disorder

Award Number: K01MH116098

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 06/01/2018

PERIOD OF PERFORMANCE END DATE: 05/31/2024

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