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7T functional MRS of metabolite variations during working memory in subjects with post-traumatic stress disorder

Award Number: K01MH115272
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 08/15/2018
PERIOD OF PERFORMANCE END DATE: 07/31/2023

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7T functional MRS of metabolite variations during working memory in subjects with post-traumatic stress disorder - In response to NOT-MH-21-120 “Administrative Supplements for COVID-19 Impacted NIMH Research,” this application seeks additional support for the principal investigator to complete the aims of the Mentored Research Scientist Development Award number K01MH115272. The goal of the research project is to examine the neural mechanisms that contribute to working memory deficits in people with posttraumatic stress disorder (PTSD). This project combines 7T resting-state magnetic resonance spectroscopy (MRS), advanced dynamic functional MRS (fMRS), and functional magnetic resonance imaging (fMRI) to investigate the relationship between neurochemistry and brain activation during working memory in PTSD. The specific aims are to (1) measure glutamate and other metabolites in the dorsolateral prefrontal cortex (DLPFC) of people with and without PTSD using resting-state MRS; (2) investigate the relationship between resting-state levels of glutamate and functional activation during the n-back working memory task in people with and without PTSD using MRS and fMRI; and (3) characterize dynamic glutamate changes during working memory in people with and without PTSD using fMRS during the n-back task. The PI has made substantial progress towards completing these aims. However, the COVID-19 pandemic has caused significant delays in recruitment and data collection. In this application, we request supplemental support for the PI to offset the loss of time due to COVID-19, complete enrollment of human subjects, and fulfill the aims of the project.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$5 )
2024	2022	AUBURN UNIVERSITY	321-A INGRAM HALL	AUBURN	AL	36849	LEE	USA	Mental Health Research Grants	000	4	4/5/2024	SUPPLEMENT FOR EXPANSION	-$5
														Subtotal = -$5

Issue Date FY: 2022 ( Subtotal = $54,000 )
2022	2022	AUBURN UNIVERSITY	107 SAMFORD HALL	AUBURN	AL	36849	LEE	USA	Mental Health Research Grants	000	4	9/7/2022	SUPPLEMENT FOR EXPANSION	$54,000
														Subtotal = $54,000

Issue Date FY: 2021 ( Subtotal = $140,911 )
2021	2021	AUBURN UNIVERSITY	107 SAMFORD HALL	AUBURN	AL	36849	LEE	USA	Mental Health Research Grants	000	4	7/12/2021	NON-COMPETING CONTINUATION	$140,911
														Subtotal = $140,911

Issue Date FY: 2020 ( Subtotal = $161,971 )
2020	2020	AUBURN UNIVERSITY	107 SAMFORD HALL	AUBURN	AL	36849	LEE	USA	Mental Health Research Grants	000	3	7/13/2020	NON-COMPETING CONTINUATION	$161,971
														Subtotal = $161,971

Issue Date FY: 2019 ( Subtotal = $160,351 )
2019	2019	AUBURN UNIVERSITY	107 SAMFORD HALL	AUBURN	AL	36849	LEE	USA	Mental Health Research Grants	000	2	7/16/2019	NON-COMPETING CONTINUATION	$160,351
														Subtotal = $160,351

Issue Date FY: 2018 ( Subtotal = $160,621 )
2018	2018	AUBURN UNIVERSITY	107 SAMFORD HALL	AUBURN	AL	36849	LEE	USA	Mental Health Research Grants	000	1	8/13/2018	NEW	$160,621
														Subtotal = $160,621

Grand Total All Awards = $677,849

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7T functional MRS of metabolite variations during working memory in subjects with post-traumatic stress disorder

Award Number: K01MH115272

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 08/15/2018

PERIOD OF PERFORMANCE END DATE: 07/31/2023

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